Graduate and Postdoc (GaP) Seminar Series
Jessilyn Dunn - Advisor, Hanjoong Jo, PhD
"Genome-scale DNA Methylation Changes in Endothelial Cells by Disturbed Flow and its Role in Atherosclerosis"
Atherosclerosis, the cause of heart attack and stroke, localizes to curves or branches in the vasculature where disturbed blood flow alters gene expression and induces endothelial cell dysfunction. The mechanism of flow-induced gene regulation via DNA methylation has not been well studied. The aim of the current study is to discover DNA methylation changes due to disturbed flow that alter gene expression and promote atherosclerosis development.
Kaitao Li - Advisor, Cheng Zhu, PhD
"Characterization of PD-1/PD-ligand Interaction and its Effects on T-cell Antigen Recognition"
PD-1 represents a promising therapeutic target, as blockade of PD-1/PD ligand has been shown to restore responses of exhausted antigen-specific T cells in a variety of chronic infectious diseases and cancer. However, there lacks a detailed description of in situ PD-1/PD-ligand interaction. The current study will provide two-dimensional analysis of such receptor-ligand interactions and their interplay with TCR-CD8-pMHC interaction.