event
Bioengineering Seminar Series
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"Design of Peptide-and Aptamer-Amphiphiles for Receptor-Targeted Therapeutics"
Efrosini Kokkoli, PhD - University of Minnesota
Drug delivery systems that include site-specific surface ligands could further enhance selective targeting. In this talk I will discuss the design and evaluation of two different ligands. The first one is a fibronectin mimetic peptide-amphiphile, PR_b, that specifically targets the alpha(5)beta(1) integrin which is over-expressed in a variety of cancer cells and on tumor vasculature, and plays an important role in angiogenesis and metastasis. PR_b functionalized nanoparticles have been evaluated in vitro and in vivo and have shown enhanced binding, intracellular uptake, and delivery of their encapsulated load compared to non-targeted and GRGDSP-functionalized particles targeted to different cancers, as well as the capability to deliver a wide variety of therapeutic cargoes. The second example is our recent effort to design a ligand for fractalkine. Fractalkine is a chemokine that acts as an adhesion molecule for leukocytes and more important is only expressed at sites of inflammation, such as cancer. We have recently identified an aptamer, FKN-S2, that binds fractalkine with high affinity and specificity. Our results demonstrate the effect of the hydrophobic tail of the aptamer-amphiphile on its self-assembly and binding characteristics.
Host: Valeria Milam, PhD
The Bioengineering Seminar Series is a joint seminar series between IBB and the BME department. Seminars are held on Tuesdays or Thursdays between 11am-12pm in IBB room 1128 unless otherwise indicated.
Status
-
Workflow Status:
Published -
Created By:
Colly Mitchell -
Created:
11/16/2011 -
Modified By:
Fletcher Moore -
Modified:
10/07/2016
Categories
Keywords
- and delivery of their encapsulated load compared to non-targeted and GRGDSP-functionalized particles targeted to different cancers
- and plays an important role in angiogenesis and metastasis. PR_b functionalized nanoparticles have been evaluated in vitro and in vivo and have shown enhanced binding
- as well as the capability to deliver a wide variety of therapeutic cargoes. The second example is our recent effort to design a ligand for fractalkine. Fractalkine is a chemokine that acts as an adhesion molecule for leukocytes and more important is only
- BioE Seminar
- Drug delivery systems that include site-specific surface ligands could further enhance selective targeting. In this talk I will discuss the design and evaluation of two different ligands. The first one is a fibronectin mimetic peptide-amphiphile
- Efrosini Kokkoli
- IBB
- intracellular uptake
- PR_b
- that specifically targets the alpha(5)beta(1) integrin which is over-expressed in a variety of cancer cells and on tumor vasculature
Target Audience