{"72842":{"#nid":"72842","#data":{"type":"event","title":"Bioengineering Seminar Series","body":[{"value":"\u003Cp\u003E\u003Cem\u003E\u003Cstrong\u003E\u0022Design of Peptide-and Aptamer-Amphiphiles for Receptor-Targeted Therapeutics\u0022\u0026nbsp;\u003C\/strong\u003E\u003C\/em\u003E\u003Cbr \/\u003E\u003Cbr \/\u003E\u003Cstrong\u003EEfrosini Kokkoli, PhD - University of Minnesota\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cbr \/\u003EDrug delivery systems that include site-specific surface ligands could further enhance selective targeting. In this talk I will discuss the design and evaluation of two different ligands. The first one is a fibronectin mimetic peptide-amphiphile, PR_b, that specifically targets the alpha(5)beta(1) integrin which is over-expressed in a variety of cancer cells and on tumor vasculature, and plays an important role in angiogenesis and metastasis. PR_b functionalized nanoparticles have been evaluated in vitro and in vivo and have shown enhanced binding, intracellular uptake, and delivery of their encapsulated load compared to non-targeted and GRGDSP-functionalized particles targeted to different cancers, as well as the capability to deliver a wide variety of therapeutic cargoes. The second example is our recent effort to design a ligand for fractalkine. Fractalkine is a chemokine that acts as an adhesion molecule for leukocytes and more important is only expressed at sites of inflammation, such as cancer. We have recently identified an aptamer, FKN-S2, that binds fractalkine with high affinity and specificity. Our results demonstrate the effect of the hydrophobic tail of the aptamer-amphiphile on its self-assembly and binding characteristics.\u003Cbr \/\u003E\u003Cbr \/\u003EHost: \u0026nbsp;\u003Ca href=\u0022mailto:valeria.milam@mse.gatech.edu\u0022\u003EValeria Milam, PhD\u003C\/a\u003E\u003C\/p\u003E\u003Cp\u003EThe Bioengineering Seminar Series is a joint seminar series between IBB and the BME department. Seminars are held on Tuesdays or Thursdays between 11am-12pm in IBB room 1128 unless otherwise indicated.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBioengineering Seminar Series - \u0022Design of Peptide- and Aptamer-Amphiphiles for Receptor-Targeted Therapeutics\u0022 -\u0026nbsp;Efrosini Kokkoli, PhD - University of Minnesota\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Design of Peptide- and Aptamer-Amphiphiles for Receptor-Targeted Therapeutics\u0022 - Efrosini Kokkoli, PhD - University of Minnesota"}],"uid":"27195","created_gmt":"2011-11-16 13:41:46","changed_gmt":"2016-10-08 01:56:41","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2012-04-26T12:00:00-04:00","event_time_end":"2012-04-26T13:00:00-04:00","event_time_end_last":"2012-04-26T13:00:00-04:00","gmt_time_start":"2012-04-26 16:00:00","gmt_time_end":"2012-04-26 17:00:00","gmt_time_end_last":"2012-04-26 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"124031":{"id":"124031","type":"image","title":"Efrosini Kokkoli, PhD - University of Minnesota","body":null,"created":"1449178593","gmt_created":"2015-12-03 21:36:33","changed":"1475894746","gmt_changed":"2016-10-08 02:45:46","alt":"Efrosini Kokkoli, PhD - University of Minnesota","file":{"fid":"194456","name":"kokkoli-800x600.jpg","image_path":"\/sites\/default\/files\/images\/kokkoli-800x600_0.jpg","image_full_path":"http:\/\/hg.gatech.edu\/\/sites\/default\/files\/images\/kokkoli-800x600_0.jpg","mime":"image\/jpeg","size":158982,"path_740":"http:\/\/hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/kokkoli-800x600_0.jpg?itok=WfOcW_wv"}}},"media_ids":["124031"],"related_links":[{"url":"http:\/\/www.cems.umn.edu\/about\/people\/faculty.php?id=20282","title":"Kokkoli profile"},{"url":"http:\/\/www.ibb.gatech.edu\/bioe-seminars","title":"BIOE Seminar Series schedule"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"30331","name":"and delivery of their encapsulated load compared to non-targeted and GRGDSP-functionalized particles targeted to different cancers"},{"id":"30311","name":"and plays an important role in angiogenesis and metastasis. PR_b functionalized nanoparticles have been evaluated in vitro and in vivo and have shown enhanced binding"},{"id":"30341","name":"as well as the capability to deliver a wide variety of therapeutic cargoes. The second example is our recent effort to design a ligand for fractalkine. Fractalkine is a chemokine that acts as an adhesion molecule for leukocytes and more important is only"},{"id":"11877","name":"BioE Seminar"},{"id":"30281","name":"Drug delivery systems that include site-specific surface ligands could further enhance selective targeting. In this talk I will discuss the design and evaluation of two different ligands. The first one is a fibronectin mimetic peptide-amphiphile"},{"id":"15097","name":"Efrosini Kokkoli"},{"id":"248","name":"IBB"},{"id":"30321","name":"intracellular uptake"},{"id":"30291","name":"PR_b"},{"id":"30301","name":"that specifically targets the alpha(5)beta(1) integrin which is over-expressed in a variety of cancer cells and on tumor vasculature"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:valeria.milam@mse.gatech.edu\u0022\u003EValeria Milam, PhD\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}