Quantitative Redox Biology Working Group Discussion
Redox processes are at the foundation of nearly all aspects of biology. In addition to free radicals, related oxidants, and antioxidants, thiol/disulfide redox regulation is central to the basic functioning of cells and tissues. All these set the cellular redox environment and therefore are key to regulation of biochemical pathways and networks, influencing organism health. To understand better how cellular redox processes connect to the metabolome, proteome, lipidome, and genome we need absolute, quantitative information on all redox active compounds as well as thermodynamic and kinetic information on their reactions, i.e. knowledge of the complete redoxome. Quantitative information is essential to establish the dynamic mathematical models needed to reveal the temporal evolution of biochemical pathways and networks. This new field of Quantitative Redox Biology will allow researchers to identify new targets for intervention to advance our efforts to achieve optimal human health.
The goal of this working group meeting is to initiate discussion on how we can help each other and the community as a whole advance research in Quantitative Redox Biology.
Please note that this event is not sanctioned by SFRBM, although the society has kindly provided meeting space for us. We will be convening primarily during the break between the SFRBM pre-meeting workshop and the President’s Welcome. The format of this working group meeting will be informal with very short presentations followed by discussion on the following topic areas:
- What is Quantitative Redox Biology (QRB)?
- What types of data are needed for QRB?
- How do we as a community organize curation of data (i.e. 'redoxome' database)?
- Should there be standardization of data reporting?
- What modeling tools are needed to advance the field?
- How can this group advance kinetic analyses of one-electron and two-electron processes? – e.g. from superoxide/metal reactions and/or H2O2/protein-cys modifications to gene expression and metabolism.
- How can we collectively improve NIH funding opportunities in QRB? .
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- Workflow Status: Published
- Created By: Floyd Wood
- Created: 10/20/2011
- Modified By: Fletcher Moore
- Modified: 10/07/2016