Sophia Mavris
BME PhD Defense Presentation

Date: 2025-06-20
Time: 9:00 - 11:00 AM
Location / Meeting Link: IBB Suddath Seminar Room 1128

Committee Members:
Rudolph L. Gleason, PhD (Advisor); J. Brandon Dixon, PhD; Laura Hansen, PhD; Lakshmi Dasi, PhD; Dhruv Singhal, MD


Title: Mechanical and Functional Characterization of Lymphatic Vasculature Through 1D Mathematical Modeling and In Vivo Analysis

Abstract:
The lymphatic system plays a vital role in maintaining fluid balance, achieved through the coordinated contractile behavior of collecting lymphatic vessels. This dissertation integrates one-dimensional (1D) computational modeling with in vivo and ex vivo experimentation to investigate how mechanical and functional properties of lymphatic vessels respond to physiological and pathological conditions. A physiologically informed 1D fluid-solid model was developed to simulate lymph transport, incorporating spatially-resolved contraction, valve dynamics, and vessel wall mechanics across various network geometries. In vivo near-infrared imaging in rat models revealed how sex, anesthesia, strain, and injury severity influence lymphatic pumping function. Complementary mechanical testing of post-injury sheep lymphatic vessels demonstrated geometric remodeling without significant changes in compliance or material properties. Together, these findings advance our understanding of lymphatic transport mechanisms and provide a foundation for predictive modeling frameworks that can guide future diagnostic and therapeutic strategies for lymphatic dysfunction.