{"682744":{"#nid":"682744","#data":{"type":"event","title":"Phd Defense by Sophia Mavris","body":[{"value":"\u003Cp\u003ESophia Mavris\u003Cbr\u003EBME PhD Defense Presentation\u003Cbr\u003E\u003Cbr\u003E\u003Cstrong\u003EDate\u003C\/strong\u003E: 2025-06-20\u003Cbr\u003E\u003Cstrong\u003ETime\u003C\/strong\u003E: 9:00 - 11:00 AM\u003Cbr\u003E\u003Cstrong\u003ELocation \/ Meeting Link\u003C\/strong\u003E: IBB Suddath Seminar Room 1128\u003Cbr\u003E\u003Cbr\u003E\u003Cstrong\u003ECommittee Members:\u003C\/strong\u003E\u003Cbr\u003ERudolph L. Gleason, PhD (Advisor); J. Brandon Dixon, PhD; Laura Hansen, PhD; Lakshmi Dasi, PhD; Dhruv Singhal, MD\u003Cbr\u003E\u003Cbr\u003E\u003Cbr\u003E\u003Cstrong\u003ETitle\u003C\/strong\u003E: Mechanical and Functional Characterization of Lymphatic Vasculature Through 1D Mathematical Modeling and In Vivo Analysis\u003Cbr\u003E\u003Cbr\u003E\u003Cstrong\u003EAbstract:\u003C\/strong\u003E\u003Cbr\u003EThe lymphatic system plays a vital role in maintaining fluid balance, achieved through the coordinated contractile behavior of collecting lymphatic vessels. This dissertation integrates one-dimensional (1D) computational modeling with in vivo and ex vivo experimentation to investigate how mechanical and functional properties of lymphatic vessels respond to physiological and pathological conditions. A physiologically informed 1D fluid-solid model was developed to simulate lymph transport, incorporating spatially-resolved contraction, valve dynamics, and vessel wall mechanics across various network geometries. In vivo near-infrared imaging in rat models revealed how sex, anesthesia, strain, and injury severity influence lymphatic pumping function. Complementary mechanical testing of post-injury sheep lymphatic vessels demonstrated geometric remodeling without significant changes in compliance or material properties. Together, these findings advance our understanding of lymphatic transport mechanisms and provide a foundation for predictive modeling frameworks that can guide future diagnostic and therapeutic strategies for lymphatic dysfunction.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":"","format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EMechanical and Functional Characterization of Lymphatic Vasculature Through 1D Mathematical Modeling and In Vivo Analysis\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Mechanical and Functional Characterization of Lymphatic Vasculature Through 1D Mathematical Modeling and In Vivo Analysis"}],"uid":"27707","created_gmt":"2025-06-10 17:35:00","changed_gmt":"2025-06-10 17:35:26","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2025-06-20T09:00:00-04:00","event_time_end":"2025-06-20T11:00:00-04:00","event_time_end_last":"2025-06-20T11:00:00-04:00","gmt_time_start":"2025-06-20 13:00:00","gmt_time_end":"2025-06-20 15:00:00","gmt_time_end_last":"2025-06-20 15:00:00","rrule":null,"timezone":"America\/New_York"},"location":"IBB Suddath Seminar Room 1128","extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"100811","name":"Phd Defense"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78771","name":"Public"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}