Micro-Physiological Systems Seminar Series

Event Details
  • Date/Time:
    • Wednesday November 20, 2019 - Thursday November 21, 2019
      1:00 pm - 1:59 pm
  • Location: Whitaker Building (BME), Room 1103
  • Phone:
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  • Fee(s):
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Shuichi Takayama, faculty host


Summary Sentence: "Bioengineered Human iPSC Tissue Model for Gaining Mechanistic and Therapeutic Insights into CPVT" - Sung-Jin Park, Ph.D. - Georgia Tech/Emory University

Full Summary: No summary paragraph submitted.

"Bioengineered Human iPSC Tissue Model for Gaining Mechanistic and Therapeutic Insights into CPVT"

Sung Jin Park, Ph.D.
Assistant Professor
Coulter Department of Biomedical Engineering
Georgia Tech/Emory University

The cellular phenotypes caused by inherited arrhythmia mutations have been studied using human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs). However, arrhythmias are the emergent properties of cells assembled into tissues, and the impact of these mutations on tissue-level properties of human myocardium has not been reported. In this talk, I will present an in vitro hiPSC-CM-based platform to study the tissue-level properties of engineered human myocardium. I will illustrate how this hiPSC-CM-based platform can be used to investigate pathogenic mechanisms in the deadly, exercise-triggered inherited arrhythmia catecholaminergic polymorphic ventricular tachycardia (CPVT). In addition, I will show how we combined this novel platform with genome editing and identified new therapeutic target for CPVT.

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Additional Information

In Campus Calendar

Parker H. Petit Institute for Bioengineering and Bioscience (IBB)

Invited Audience
Postdoc, Graduate students
go-PetitInstitute, IBB
  • Created By: Floyd Wood
  • Workflow Status: Published
  • Created On: Nov 8, 2019 - 10:20am
  • Last Updated: Nov 8, 2019 - 10:26am