Micro-Physiological Systems Seminar Series

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"Bioengineered Human iPSC Tissue Model for Gaining Mechanistic and Therapeutic Insights into CPVT"

Sung Jin Park, Ph.D.
Assistant Professor
Coulter Department of Biomedical Engineering
Georgia Tech/Emory University

The cellular phenotypes caused by inherited arrhythmia mutations have been studied using human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs). However, arrhythmias are the emergent properties of cells assembled into tissues, and the impact of these mutations on tissue-level properties of human myocardium has not been reported. In this talk, I will present an in vitro hiPSC-CM-based platform to study the tissue-level properties of engineered human myocardium. I will illustrate how this hiPSC-CM-based platform can be used to investigate pathogenic mechanisms in the deadly, exercise-triggered inherited arrhythmia catecholaminergic polymorphic ventricular tachycardia (CPVT). In addition, I will show how we combined this novel platform with genome editing and identified new therapeutic target for CPVT.


  • Workflow Status: Published
  • Created By: Floyd Wood
  • Created: 11/08/2019
  • Modified By: Floyd Wood
  • Modified: 11/08/2019