{"628780":{"#nid":"628780","#data":{"type":"event","title":"Micro-Physiological Systems Seminar Series","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0026quot;Bioengineered Human iPSC Tissue Model for Gaining Mechanistic and Therapeutic Insights into CPVT\u0026quot;\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003E\u003Cstrong\u003ESung Jin Park, Ph.D.\u003Cbr \/\u003E\r\nAssistant Professor\u003Cbr \/\u003E\r\nCoulter Department of Biomedical Engineering\u003Cbr \/\u003E\r\nGeorgia Tech\/Emory University\u003C\/strong\u003E\u003C\/p\u003E\r\n\r\n\u003Cp\u003EThe cellular phenotypes caused by inherited arrhythmia mutations have been studied using human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs). However, arrhythmias are the emergent properties of cells assembled into tissues, and the impact of these mutations on tissue-level properties of human myocardium has not been reported. In this talk, I will present an in vitro hiPSC-CM-based platform to study the tissue-level properties of engineered human myocardium. I will illustrate how this hiPSC-CM-based platform can be used to investigate pathogenic mechanisms in the deadly, exercise-triggered inherited arrhythmia catecholaminergic polymorphic ventricular tachycardia (CPVT). In addition, I will show how we combined this novel platform with genome editing and identified new therapeutic target for CPVT.\u003C\/p\u003E\r\n","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"\u0022Bioengineered Human iPSC Tissue Model for Gaining Mechanistic and Therapeutic Insights into CPVT\u0022 - Sung-Jin Park, Ph.D. - Georgia Tech\/Emory University"}],"uid":"27349","created_gmt":"2019-11-08 15:20:45","changed_gmt":"2019-11-08 15:26:44","author":"Floyd Wood","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2019-11-20T13:00:00-05:00","event_time_end":"2019-11-20T14:00:00-05:00","event_time_end_last":"2019-11-20T14:00:00-05:00","gmt_time_start":"2019-11-20 18:00:00","gmt_time_end":"2019-11-20 19:00:00","gmt_time_end_last":"2019-11-20 19:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"https:\/\/www.biohybridlab.org\/","title":"Park website"},{"url":"https:\/\/pwp.gatech.edu\/biomicrofluidics\/","title":"Seminar website"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"126571","name":"go-PetitInstitute"},{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"177814","name":"Postdoc"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:takayama@gatech.edu\u0022\u003EShuichi Takayama\u003C\/a\u003E, faculty host\u003C\/p\u003E\r\n","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}