Nano@Tech: Engineered Bionanocomposites for Biosensing and Bioelectronics

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Engineered Bionanocomposites for Biosensing and Bioelectronics

Vladimir V. Tsukruk
School of Materials Science and Engineering,
Georgia Institute of Technology

Abstract: I will discuss recent results from our research group on designing robust, flexible, actuating, and responsive nanoscale multilayered hybrid nanomaterials for biosensing and bioelectronic applications.[i],[ii]  Ultrathin shells from synthetic and natural materials are assembled in order to conduct surface modification and protection of model microparticles, cells and cell assemblies.[iii]  Microcapsules designed here are formed at interfaces from various linear and branched synthetic and biological macromolecules and graphene oxide assembled via hydrogen-bonding, ion pairing, and hydrophobic-hydrophobic interactions and tunable by temperature, pH or illumination of solutions.[iv]  Various means are further exploited to transfer the LbL shells on various bacterial cells and place them in larger encapsulated cell arrays for bio-colometric detection.[v]  Ultra strong laminated bionanocomposites from silk and graphene oxide components with unique interphase morphology were found to possess extremely high elastic modulus and toughness[vi] as well conductive patterning with localized electrochemical reduction.[vii],[viii]

[i] C. Ye, V. V. Tsukruk, Designing two-dimensional materials that spring rapidly into three-dimensional shapes, Science, 2015, 347, 130.

[ii] I. Drachuk et al., Biomimetic coatings to control cellular function through cell surface engineering, Adv. Funct. Mater., 2013, 23, 4437.
Drachuk, I. et al. pH-Responsive LbL Nanoshells for Direct Regulation of Cell Activity, ACS Nano, 2012, 6, 4266.
W. Xu,et al. Non-destructive light-initiated tuning of LbL microcapsule permeability, ACS Nano, 2013, 7, 598.
R. Suntivich, et al., Inkjet printing of silk nest arrays for cell hosting, Biomacromolecules, 2014, 15, 1428
K. Hu, et al. Ultra-Robust Graphene Oxide-Silk Fibroin Nanocomposite Membranes, Adv. Mater., 2013, 25, 2301.
Hu, K. et al. Written-in Conductive Patterns on Robust Graphene Oxide Biopaper by Electrochemical Microstamping. Angew. Chem. Int. Ed., 2013, 52, 1378.
D. D. Kulkarni, et al, Chemical Reduction of Individual Graphene Oxide Sheets as Revealed by Electrostatic Force Microscopy, J. Am. Chem. Soc., 2014, 136, 6546.

Bio: Vladimir V. Tsukruk received his MS degree in physics from the National University of Ukraine, PhD in polymers and DSc in chemistry and polymer science from the National Academy of Sciences of Ukraine. He carried out his post-doc research at the U. Marburg, Darmstadt TU, and U. Akron. He is currently a Professor at the School of Materials Science and Engineering, Georgia Institute of Technology and a Director of Microanalysis Center. He serves on the editorial advisory boards of seven professional journals, has co-authored around 390 refereed articles in archival journals, as well as five books, has organized ten professional symposia, and trained about 60 students and post-docs. His research in the field of surfaces, interfaces, and molecular assembly of synthetic and natural polymers, nano- and bioinspired hybrid nanomaterials has been recognized by the Humboldt Research Award (2009) and the NSF Special Creativity Award (2006), among others. He was elected as an APS Fellow in 2010, a MRS Fellow in 2011, and an ACS Fellow in 2014. His recent book (V. V. Tsukruk, S. Singamaneni: Scanning Probe Microscopy of Soft Matter: Fundamentals and Practices, Wiley, 2012) is a popular comprehensive textbook on SPM applications of synthetic and biological materials.


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