Prof. Thomas Müller, Duesseldorf

Multi-component Synthesis of Heterocycles and Domino Reactions Initiated by Palladium Catalysis

Palladium-catalyzed processes such as Sonogashira alkynylation or Alder-ene-cycloisomerization are excellent entries to domino sequences,1 and sequential and consecutive multi-component syntheses of numerous classes of heterocycles.2,3 Besides for functional chromophores4 this synthetic concept can be adapted for short and even one-pot syntheses of natural products and pharmaceuticals with antiparasital or kinase inhibitory activity.

In the lecture the concept will be introduced and outlined and representative examples will be discussed.

1. a) D. M. D'Souza, F. Rominger, T. J. J. Müller, Chem. Commun. 2006, 4096. b) D. M. D'Souza, F. Rominger, T. J. J. Müller, Angew. Chem. Int. Ed. 2005, 44, 153.
2. a) T. J. J. Müller in "Metal Catalyzed Cascade Reactions", T. J. J. Müller, ed., Springer Berlin/Heidelberg, Top. Organomet. Chem. 2006, 19, 149. b) N. Körber, T. J. J. Müller, Chimica Oggi/Chemistry Today 2006, 24(5), 22.
3. Recent reviews on multi-component syntheses of heterocycles, see e.g. a) T. J. J. Müller, Chimica Oggi/Chemistry Today 2007, 25(1), 70. b) D. M. D'Souza, T. J. J. Müller, Chem. Soc. Rev. 2007, 36, 1095. c) T. J. J. Müller, Targets in Heterocyclic Systems 2007, 10, 54.
4. Recent review on diversity oriented synthesis of π-systems, T. J. J. Müller in Functional Organic Materials - Synthesis, Strategies, and Applications, T. J. J. Müller, U. H. F. Bunz, eds., Wiley-VCH, Weinheim, 2007, 179.

For more information contact Prof. Uwe Bunz (404-385-1795).