(11-0215) Prof. Kevin Bucholtz, Mercer University

Event Details
  • Date/Time:
    • Tuesday February 15, 2011 - Wednesday February 16, 2011
      3:00 pm - 3:59 pm
  • Location: MoSE 3201A
  • Phone:
  • URL:
  • Email:
  • Fee(s):
    N/A
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Contact
Shirley Tomes
Chemistry & Biochemistry
Contact Shirley Tomes
404-894-0591
Summaries

Summary Sentence: Prof. Kevin Bucholtz, Mercer University

Full Summary: Prof. Kevin Bucholtz, Mercer University PPAR δ and 3β-HSD1: Two Stories in Ligand Selectivity Organic Chemistry Seminar Series

Prof. Kevin Bucholtz, Mercer University

PPAR δ and 3β-HSD1: Two Stories in Ligand Selectivity

Organic Chemistry Seminar Series

Peroxisome Proliferator Activated Receptors (PPAR) are nuclear hormone receptors that are of great interest because of their implications in the metabolic syndrome. The isotype PPAR δ, a ligand activated transcription factor, is of significant interest since little is known about its role in biological phenomena. The human type isoform of 3β-hydroxysteroid dehydrogenase/ isomerase (3β-HSD1) is a key enzyme in the biosynthesis of active steroid hormones. Human 3β-HSD1 is a critical enzyme in the conversion of dehydroepiandrosterone (DHEA) to estradiol in breast tumors. Both of these biomacromolecules (PPAR δ and 3β-HSD1) have been the focus of rationally designed small molecules to selectively interact with each target and used to determine the characteristics of the interaction. The biological implications of these small molecule interactions are currently being investigated.

for more information contact Prof. Wendy Kelly (404-385-1154).

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Additional Information

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School of Chemistry and Biochemistry

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Categories
Seminar/Lecture/Colloquium
Keywords
Biochemistry
Status
  • Created By: Shirley Tomes
  • Workflow Status: Published
  • Created On: May 5, 2010 - 8:00pm
  • Last Updated: Oct 7, 2016 - 9:47pm