(11-0207) Prof. Nicole Sampson, Stony Brook University

Event Details
  • Date/Time:
    • Monday February 7, 2011 - Tuesday February 8, 2011
      3:00 pm - 3:59 pm
  • Location: MoSE 3201A
  • Phone:
  • URL:
  • Email:
  • Fee(s):
    N/A
  • Extras:
Contact
Shirley Tomes
Chemistry & Biochemistry
Contact Shirley Tomes
404-894-0591
Summaries

Summary Sentence: Prof. Nicole Sampson, Stony Brook University

Full Summary: Prof. Nicole Sampson, Stony Brook University Mycobacteria on Steroids: Metabolomics and Pathogenesis

Prof. Nicole Sampson, Stony Brook University

Mycobacteria on Steroids: Metabolomics and Pathogenesis

New drugs with novel mechanisms of action are required to meet the severe threat to human health posed by the emergence of multidrug and extensively drug resistant strains of M. tuberculosis (M. tb). The ability of M. tb to metabolize cholesterol is critical for the maintenance of the M. tb infection; both the igr operon and fadA5 are required for in vitro growth using cholesterol as a sole carbon source. However, mutation of these genes involved in cholesterol metabolism results in different in vivo phenotypes. We are elucidating the function of these genes, their corresponding enzymes, and their role in cholesterol metabolism using a combination of transcriptional profiling, bioinformatics, enzymology, biochemistry, and metabolic phenotype screening. Ultimately, understanding cholesterol metabolism at the molecular level will direct drug discovery towards novel targets that attenuate M. tb growth and persistence in vivo.

For more information contact Prof. Andrew Lyon (404-894-4090).

Related Links

Additional Information

In Campus Calendar
No
Groups

School of Chemistry and Biochemistry

Invited Audience
No audiences were selected.
Categories
Seminar/Lecture/Colloquium
Keywords
Biochemistry
Status
  • Created By: Shirley Tomes
  • Workflow Status: Published
  • Created On: Jan 5, 2011 - 8:00pm
  • Last Updated: Oct 7, 2016 - 9:46pm