Orthonics, Inc., an Atlanta start-up company developing new biomaterials for spinal disc repair and regeneration, has received initial funding from Viscogliosi Brothers, LLC, a New York-based closely held venture capital/private equity and merchant banking firm focused on the musculoskeletal/orthopedics industry. Terms of the funding were not disclosed.

The funding provides the private-sector match for the company's Phase II grant from VentureLab, a Georgia Research Alliance program that encourages commercialization of technologies developed in Georgia's research universities. The funding will allow Orthonics to continue development of its spinal disc repair and regeneration technologies, which are based on research from the Georgia Institute of Technology.

Spinal discs are tough, rubbery materials that separate vertebrae in the spinal column. When damaged, they can press on nerves and cause pain. Surgeons can remove the damaged disc and fuse the spinal vertebrae, but that procedure greatly limits motion in the back. Orthonics' novel biomaterials could provide a non-fusion alternative in the more than one million spinal surgical procedures that take place each year - an estimated $3 billion market.

"We're extremely pleased with this investment. The Viscogliosi Brothers have an outstanding track record in orthopedics and their investment in Orthonics is a great endorsement of our business plan and technology," said Orthonics CEO Steve Kennedy. Both parties expect that Viscogliosi Brothers will be the lead investor in a round of seed financing to take place in a few months.

Orthonics' technology is based on research from the laboratory of Barbara Boyan, the Price Gilbert, Jr. Chair in Tissue Engineering and deputy director of research for the Georgia Tech/Emory Center for the Engineering of Living Tissues. (Boyan is also the Georgia Research Alliance Eminent Scholar in Tissue Engineering.) The company's technology includes an improved hydrogel biomaterial and a novel surface patterning technique used to create a more natural attachment between the artificial material and bone or cartilage tissues.

"We have a technique for creating micropatterns on the biomaterial's surface that cause cells in contact with it to behave in a specific way," Kennedy said. "By designing the surface properly, we can cause cells that are precursors to bone cells to become bone cells and start making bone, and we can cause cells that are precursors to cartilage cells to become cartilage cells and start making cartilage."

The ability to control cell differentiation and cause the incorporation of new bone and cartilage tissue into the artificial material may allow Orthonics' devices to replace or repair portions of the spinal disc while eliminating the need for devices such as screws for attaching the company's "bionic" materials to spinal vertebrae.

"The natural cells that are in contact with the prosthetic device are tricked into thinking that it is bone, and this causes them to attach to the biomaterial and start growing new bone or cartilage," he explained. "The device will then become naturally attached to the bone. This eliminates the need for spikes and screws and allows us to repair just the damaged portion of the disc annulus or nucleus without having to replace the entire disc. We also expect to be able to repair the facet joints in the spinal column to relieve the debilitating pain associated with the degeneration of those joints."