Bioengineering Seminar Series

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"In Vitro modeling of Endothelial Cell Response to Wall Shear Stress: Now in 3D"

Richard Leask, PhD - Associate Professor, McGill University

Host: Ian Copland, PhD

Atherosclerosis is known to occur in regions of complex blood flow such as near bifurcations and areas of curvature. Although many risk factors have been identified, none can explain the focal nature of the disease. It is now widely accepted that the local variations in the forces created by blood flow (hemodynamic forces) play a causal role in the development and progression of most cardiovascular diseases. In vitro cell culture studies have been fundamental to our understanding of how endothelial cells sense and respond to hemodynamic forces. In this talk I will describe some of the work my laboratory has done to develop in vitro, three-dimensional models to investigate endothelial cell and blood component response to hemodynamic forces. The effects of wall shear stress on endothelial cell morphology, phenotype, leukocyte attachment and response to statin therapy will be presented.

Prof. Leask received his B.A.Sc. and M.A.Sc from the University of Waterloo in 1994 and 1996 respectively, and a PhD from the University of Toronto in 2002. He is an Associate Professor in the Department of Chemical Engineering at McGill and a Researcher at the Montreal Heart Institute. Dr. Leask holds a McGill William Dawson Research Chair and a Ministère de l'Éducation, du Loisir et du Sport (MELS) Teaching Chair.

The Bioengineering Seminar Series is a joint seminar series between IBB and the BME department. Seminars are held on Tuesdays or Thursdays between 11am-12pm in IBB room 1128 unless otherwise indicated.  


  • Workflow Status:Published
  • Created By:Colly Mitchell
  • Created:11/16/2011
  • Modified By:Fletcher Moore
  • Modified:10/07/2016