Research
Defining structure-function relationships in biomolecules is essential to understanding their biological function, role in disease, and utility as therapeutic targets. We pursue a broad range of structure determination efforts using integrated techniques in state-of-the-art X-ray crystallography, cryo-electron microscopy (cryo-EM), and solution nuclear magnetic resonance (NMR) spectroscopy. The problems we tackle are challenging and often require support from computational modeling, guided by experimental data. We also seek to define dynamics behavior, conformational plasticity, and allostery in proteins, protein/protein assemblies, and protein/lipid assemblies.

Bio 
Andrew McShan's expertise spans biophysics, structural biology, computational biology, and immunology. They joined the faculty at Georgia Tech as an Assistant Professor in the School of Chemistry and Biochemistry in Summer 2022. Previously, they were a postdoctoral fellow in the lab of Nikolaos Sgourakis at the Children's Hospital of Philadelphia & The University of Pennsylvania (2020-2022) studying antigen presentation of classical peptide/MHC-I molecules and also with the Sgourakis lab at the University of California, Santa Cruz (2016-2020). They also worked as a biotechnology intern in the lab of Y. John Wang at Genentech (2015). They obtained their Ph.D. in Molecular, Cellular & Developmental Biology at the University of Kansas in the lab of Roberto De Guzman (2011-2016) studying bacterial type III section systems. They carried out undergraduate research in epigenetics (also at KU) in the lab of Justin Blumenstiel.

The IBB Breakfast Club Seminar Series was started with the spirit of the Institute's interdisciplinary mission in mind to feature local IBB faculty member's research in a seminar format. Faculty are often asked to speak at other universities and conferences, but do not often present at their home institution - this seminar series is an attempt to close that gap. IBB Breakfast Club Seminars are open to anyone in the bio-community.