The objective of the proposed research is to enable the creation of analog very large scale integrated (AVLSI) systems. As computation demand increases, the energy costs of current digital approaches are rapidly becoming unsustainable. AVLSI systems have shown the potential to perform extremely energy efficient computation, as demonstrated by  our brains. However, true AVLSI does not currently exist because analog design lacks the spark that lit the digital VLSI revolution: Tools. Digital tools can exist because of the homogeneity in digital standard cells, enabling high level abstract frameworks that free designers to concentrate on architectural questions. One of those architectures, the Manhattan architecture found in Field Programmable Gate Arrays (FPGAs), has led to efficient reconfigurable systems. This work transposes digital VLSI history into the analog domain by enabling tools through a programmable analog standard cell framework and by using the Manhattan architecture with programmable analog circuits for efficient computing.