The objective of the proposed research is to further develop wearable and bio-integrated electronics as transformative tools for non-invasive, real-time human bio-signal data collection to manage chronic diseases, facilitate early diagnosis, and next human-machine interfaces. Wearables, designed for everyday use, intelligently capture signals, and offer enhanced functionality with minimal user input. However, despite advancements in bio-compatible sensors and wearable electronics, there is an ongoing challenge in creating integrated systems that can effectively interpret biopotential signals into actionable biomarkers. Here, this proposal introduces a novel system of wearable electronics: an all-in-one soft electronic platform integrating a wireless 20-channel multi-sensing system for comprehensive at-home health monitoring, a battery-less heart monitor for ambient electrocardiogram tracking, and a silent speech wearable interface, using continuous facial and transcutaneous motion sensing.  These innovations not only overcome hardware and data bottlenecks but also provide a single, multi-modal signal acquisition pathway to capture and interpret complex neurological data efficiently. This advancement significantly enhances personalized and non-intrusive healthcare, improving ambient connectivity and daily convenience. It marks a milestone in the evolution of wearables, setting the stage for future advancements in intelligent systems and human-machine interfaces.