Phd Proposal by Boeun Hwang

Event Details
  • Date/Time:
    • Thursday October 20, 2022
      1:00 pm - 3:00 pm
  • Location: ECC 402
  • Phone:
  • URL: Zoom
  • Email:
  • Fee(s):
    N/A
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Summaries

Summary Sentence: : 3D Bioprinting of Perfusable Vascular Cardiac Patches to Treat Myocardial Infarction

Full Summary: No summary paragraph submitted.

Boeun Hwang

BME PhD Proposal Presentation


Date: 2022-10-20
Time: 1:00 - 3:00 PM
Location / Meeting Link: ECC 402 / https://emory.zoom.us/j/97539253040

Committee Members:
Vahid Serpooshan, PhD (Advisor); Jianyi (Jay) Zhang, MD, PhD; Holly Buaser-Heaton, MD, PhD; Rebecca Levit, MD; Michael Davis, PhD


Title: 3D Bioprinting of Perfusable Vascular Cardiac Patches to Treat Myocardial Infarction

Abstract:
Cardiac patches have been a promising tissue engineering strategy to restore the damaged myocardium after myocardial infarction (MI). Here we propose the development of a perfusable vascular cardiac patch system using 3D bioprinting technology. 3D bioprinting allows reproducible fabrication of tissue engineered structures with high resolution. Therefore we would be able to incorporate vasculature that can mimic native tissue vessels and enhance diffusion within the patch. These cardiac patches will be functionalized by loading cellular components and pro-proliferative molecules. We will encapsulate endothelial cells (ECs) and human induced stem cell-derived cardiomyocytes (hiPSC-CMs) to cellularize the patches. Further, pro-proliferative factors such as Follistatin-like protein 1 (FSTL1) and CHIR99021 will be loaded into the patch to promote cardiomyocyte proliferation within the patch and at the injury site. In this study, we aim to establish the 3D bioprinted perfusable cardiac patch with ECs, hiPSC-CMs, FSTL1, and CHIR99021 and evaluate its therapeutic potential to improve cardiac function after MI. This thesis will provide insights on the development of novel patch devices to regenerate heart tissue and the 3D patch platform could further be utilized to understand various cardiac regeneration mechanisms.

Additional Information

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Graduate Studies

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Faculty/Staff, Public, Undergraduate students
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Keywords
Phd proposal
Status
  • Created By: Tatianna Richardson
  • Workflow Status: Published
  • Created On: Oct 14, 2022 - 5:12pm
  • Last Updated: Oct 14, 2022 - 5:12pm