PhD Proposal by Olga Brazhkina

Event Details
  • Date/Time:
    • Tuesday March 29, 2022
      9:00 am - 11:00 am
  • Location: ECC 302
  • Phone:
  • URL: Zoom
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Summaries

Summary Sentence: Auxetic cardiac patch for iPSC-derived cardiomyocyte maturation and heart repair

Full Summary: No summary paragraph submitted.

Olga Brazhkina
BME PhD Proposal Presentation

Date:2022-03-29
Time: 9-11 AM
Location / Meeting Link: ECC 302 / https://emory.zoom.us/j/96962493106

Committee Members:
Michael E. Davis, PhD (Advisor) Scott Hollister, PhD Vahid Serpooshan, PhD Johnna Temenoff, PhD Yuhang Hu, PhD


Title: Auxetic cardiac patch for iPSC-derived cardiomyocyte maturation and heart repair

Abstract: Myocardial infarction is one of the largest contributors to cardiovascular disease and reduces the ability of the heart to pump blood. One promising therapeutic approach to address the diminished function is the use of cardiac patches composed of biomaterial substrates and cardiac cells. New designs to cardiac patches, such auxetic geometries that can expand in multiple directions when stretched longitudinally, can have high energy absorption, and can be modified to suit the mechanics of the infarct and surrounding cardiac tissue. These desirable qualities would be an ideal platform to investigate if auxetic patches can provide a supportive environment for cardiomyocyte function. This project seeks to develop an auxetic composite PCL/GelMA cardiac patch that can support induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) function, serve as a platform for iPSC-CM maturation, and be therapeutically used to improve cardiac function in a rat ischemia reperfusion injury model. Aim 1 will focus on designing an auxetic cardiac patch capable of supporting iPSC-CM function. Aim 2 will determine maturation potential of iPSC-CM within the auxetic cardiac patch under cyclic loading conditions and combination stimulation strategies. Finally, Aim 3 will evaluate therapeutic cardiac function in vivo after patch delivery following MI. Taken together these aims can demonstrate the validity of using auxetics for long-term cardiomyocyte culture and maturation, as well as tissue engineering approaches to treating cardiovascular disease.

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Graduate Studies

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PhD Proposa
Status
  • Created By: Tatianna Richardson
  • Workflow Status: Published
  • Created On: Mar 9, 2022 - 10:42am
  • Last Updated: Mar 9, 2022 - 10:42am