PhD Proposal by Dongsuk Sung

Event Details
  • Date/Time:
    • Thursday March 10, 2022
      10:00 am - 12:00 pm
  • Location: HSRB E160, Emory University
  • Phone:
  • URL: Zoom
  • Email:
  • Fee(s):
    N/A
  • Extras:
Contact
No contact information submitted.
Summaries

Summary Sentence: Combined MR thermometry and first-principles modeling of brain temperature for applications in injury and ischemia

Full Summary: No summary paragraph submitted.

Dongsuk Sung
BME PhD Proposal Presentation

Date:2022-03-10
Time: 10am - 12pm
Location / Meeting Link: HSRB E160, Emory University / Link: https://emory.zoom.us/j/2780087541?pwd=cTRqekt3ajFjUTZEczFHclBrdFlNdz09

Committee Members:
Candace C. Fleischer, PhD (Advisor) John Oshinski, PhD Andrei G. Fedorov, PhD Shella D. Keilholz, PhD David Reiter, PhD Jason W. Allen, MD, PhD


Title: Combined MR thermometry and first-principles modeling of brain temperature for applications in injury and ischemia

Abstract: Many brain activities are sensitive to temperature fluctuations. The brain regulates the thermal environment by maintaining a balance between metabolic heat generation and circulatory heat dissipation. Nonetheless, the balance can be disrupted by brain trauma or ischemia. While small temperature increase can induce thermal injury, this is difficult to assess as brain thermometry is not practically used in clinics. Core body temperature is used as a surrogate of brain temperature; however, the correlation between the two is decoupled after injury or ischemia. Although the increase of brain-body temperature difference is related to worse patient outcomes indicating possible tissue injury, a lack of knowledge in brain temperature disturbs decisions for appropriate therapeutic hypothermia. There is an urgent clinical need for brain thermometry to aid in decision about target cooling temperature and duration for better patients’ outcome. To incorporate brain temperature measurements in clinical routine, improved data quality across the whole brain and faster acquisition is necessary. To address these issues, we propose 1) advanced brain thermometry with improved signal-to-noise ratios and less susceptibility artifacts and 2) a biophysical model to estimate whole brain temperature maps using structural data acquired in clinical routine. Lastly, we will investigate clinical applicability of these innovative approaches for brain thermometry in patients with cardiac arrest, traumatic brain injury, and ischemic stroke. Overall, the long-term objective of the proposed research is to use brain temperature as a potential prognostic marker for better clinical outcomes and improved quality of life for patients with brain trauma or ischemia.

Additional Information

In Campus Calendar
No
Groups

Graduate Studies

Invited Audience
Faculty/Staff, Public, Undergraduate students
Categories
Other/Miscellaneous
Keywords
Phd proposal
Status
  • Created By: Tatianna Richardson
  • Workflow Status: Published
  • Created On: Feb 24, 2022 - 11:50am
  • Last Updated: Feb 24, 2022 - 11:50am