Microphysiological Seminar Series

Event Details
  • Date/Time:
    • Thursday April 14, 2022
      4:00 pm - 5:00 pm
  • Location: Virtual Event - see description for participation info
  • Phone:
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Yong Tu - event inquiries


Summary Sentence: "Biomechanical Imaging of Cells, Extracellular Matrix, and Cancer Invasion in 3D" - Ming Guo, Ph.D. - Massachusetts Institute of Technology

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VIRTUAL EVENT - Participation Link

"Biomechanical Imaging of Cells, Extracellular Matrix, and Cancer Invasion in 3D"

Ming Guo, Ph.D.
Associate Professor
Class 1954 Career Development Chair
Department of Mechanical Engineering
Massachusetts Institute of Technology

Sculpting of structure and function of three-dimensional multicellular tissues depend critically on the spatial and temporal coordination of cellular physical properties. Yet the organizational principles that govern these events, and their disruption in disease, remain poorly understood. Here, I will introduce several of our recent work in understanding cell and extracellular matrix (ECM) mechanics, as well as their mechanical interactions in 3D. I will then focus on discussing a recent progress to map the spatial and temporal evolution of positions, motions, and physical characteristics of individual cells throughout a growing mammary cancer model. Compared with cells in the tumor core, cells at the tumor periphery and the invasive front are found to be systematically softer, larger and more dynamic. These mechanical changes are shown to arise from supracellular fluid flow through gap junctions, suppression of which delays transition to an invasive phenotype. Together, these findings highlight the role of spatiotemporal coordination of cellular physical properties in tissue organization and disease progression. If time allows, I will also discuss our recent progress in demonstrating impact of cell mechanics in cell and tissue biological functions.

Additional Information

In Campus Calendar

Parker H. Petit Institute for Bioengineering and Bioscience (IBB), Wallace H. Coulter Dept. of Biomedical Engineering

Invited Audience
Faculty/Staff, Postdoc, Public, Graduate students, Undergraduate students
  • Created By: Colly Mitchell
  • Workflow Status: Published
  • Created On: Jan 25, 2022 - 1:38pm
  • Last Updated: Apr 5, 2022 - 12:06pm