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"Multiscale Optical Imaging of the Cerebral Vasculature”

Bernard Choi, Ph.D.
Professor, Biomedical Engineering
Professor, Surgery
Associate Director, Beckman Laser Institute and Medical Clinic
University of California, Irvine
 

ABSTRACT
Recent developments in photonic technologies, optical molecular probes, and transgenic animal models have led to remarkable advances in visualization of biological structures and processes.  I will discuss our ongoing efforts to image and characterize rodent cerebrovascular structure and function, with two primary applications: 1) cardiac arrest and resuscitation, and 2) Alzheimer’s disease and related disorders.  An emphasis will be placed on the constant push-pull between scientific questions of interest and development and application of optical technologies and methodologies to address these questions.  Specifically, laser speckle imaging, spatial frequency domain imaging, and thick-tissue optical clearing will be discussed.

Faculty Host: Dr. Erin Buckley