Enhancing Solute Transport in Immature Cartilage and Engineered Tissue Constructs

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Faculty host:  Robert Guldberg 404.894.6589


Summary Sentence: Gerard Ateshian, PhD - Columbia University

Full Summary: BIOE Seminar Series"Enhancing Solute Transport in Immature Cartilage and Engineered Tissue Constructs"Gerard Ateshian, PhD - Columbia University

BIOE Seminar Series

Osteoarthritis (OA) is a debilitating degenerative disease that afflicts an estimated 27 million Americans age 25 and older.  This disease leads to the progressive degradation of the articular layers of diarthrodial joints, significantly compromising the main function of cartilage as a load bearing material, leading to pain and limiting activities of daily living.  Cartilage functional tissue engineering is a highly promising technology that aims to provide a biological replacement to worn articular layers, as a modality that considerably expands the limited options in the treatment of this disease.  Though cartilage degeneration is occasionally limited to small focal areas within articular layers, OA generally becomes symptomatic when degradation has spread over much greater surface areas (such as greater than 25 percent of the articular layer). Unfortunately, functional tissue engineering of large cartilage constructs is significantly constrained by the balance of nutrient transport and consumption.  Several studies have shown that matrix deposition and elaboration of functional properties preferentially occurs near the periphery of constructs, where nutrient supply from the surrounding culture medium is most abundant, whereas cells in the interior receive less nutrients and produce less matrix, with poorer functional properties. In this presentation, we show that dynamic mechanical loading can enhance solute transport by up to an order of magnitude, and this enhancement can be considerably accelerated by placing channels in the constructs.

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Parker H. Petit Institute for Bioengineering and Bioscience (IBB)

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BIOE Seminar Series, Enhancing Solute Transport in Immature Cartilage and Engineered Tissue Constructs, Georgia Tech, Gerard Ateshian, IBB
  • Created By: Colly Mitchell
  • Workflow Status: Published
  • Created On: Mar 8, 2011 - 6:36am
  • Last Updated: Oct 7, 2016 - 9:54pm