PhD Defense by Chen Jiang
THE SCHOOL OF MATERIALS SCIENCE AND ENGINEERING GEORGIA INSTITUTE OF TECHNOLOGY Under the provisions of the regulations for the degree DOCTOR OF PHILOSOPHY on Tuesday, April 13, 2021 1:00 PM via BlueJeans Video Conferencing https://gatech.bluejeans.com/447437285 will be held the DISSERTATION DEFENSE for Chen Jiang "Design, Fabrication and Characterization of Electrospun Fibers, Yarns, and Scaffolds for Textile-inspired Tissue Engineering" Committee Members: Prof. Ben Wang, Advisor, ISYE/MSE Prof. Preet Singh, MSE Prof. Naresh Thadhani, MSE Kevin Wang, Ph.D., GTMI Prof. Youjiang Wang, MSE Abstract: This dissertation focuses on the design, fabrication, and characterization of electrospun fibers, yarns, and scaffolds, which are building blocks of textile-based tissue engineering, an important field in regenerative medicine. This study proved the hypothesis that textile-based tissue engineering would yield artificial tissues with similar physical, biological, and mechanical properties as their natural counterparts. For fibers, I investigated cell adhesion, proliferation, and morphology on electrohydrodynamic (EHD) direct-written fibers with controllable surface roughness. The results provided guidelines about controlling the surface roughness of single fibers to achieve desirable cell responses. For yarns, I investigated the mechanism of wet electrospinning and fabricated yarns with controllable mechanical properties. For scaffolds, I assembled wet electrospun yarns into scaffolds via textile technology for two case studies. The results indicated that the textile-based scaffolds could satisfy the physical, biological, and mechanical requirements for skin and vascular tissue engineering. This study will enhance the robustness of textile technology in tissue engineering and provide new perspectives for the design and fabrication of scaffolds. The modified electrospinning technology will greatly extend the usefulness of electrospinning in tissue engineering and related fields.
- Workflow Status: Published
- Created By: Tatianna Richardson
- Created: 04/01/2021
- Modified By: Tatianna Richardson
- Modified: 04/01/2021