Microphysiological Seminar Series - "Brain Organoids"

Event Details
  • Date/Time:
    • Friday March 26, 2021
      4:00 pm - 5:00 pm
  • Location: Virtual Event - see description for participation info
  • Phone:
  • URL:
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  • Fee(s):
  • Extras:

Tong Yu - Georgia Tech event organizer
Shuichi Takayama, Ph.D. - faculty advisor


Summary Sentence: Presentations from Hang Lu, Ph.D. and Melissa Cadena - Georgia Tech

Full Summary: No summary paragraph submitted.


Multi-cellular engineered living systems (M-CELS) are purpose-driven living systems with multiple interacting living components. They are engineered for specific goals or functions but take emergence into account during the design process, allowing the final system to emerge through natural and non-natural biological processes.

M-CELS research is intended to provide a fundamental engineering understanding that enables a quantitative approach bridging between single cells and organs or organisms.

Thank you for joining us for this MCELS Seminar discussing brain organoids. 


  • 4:00 p.m."What Does the Developing Brain Want?" - Hang Lu, Ph.D., Love Family Professor of Chemical and Biomolecular Engineering, Georgia Tech
  • 4:30 p.m."Engineering the Next Generation of Organoids" - Melissa Cadena, Graduate Student - Steven Sloan, Ph.D., Advisor, Georgia Tech
  • 5:00 p.m. - Adjourn


"What Does the Developing Brain Want?" - Hang Lu, Ph.D.
Brain organoids are promising systems for studying developmental, psychiatric, and other neurological diseases. With the possibility of using patient derived cells, they provide a platform for mechanistic studies as well as drug screens. The holy grail has been how to direct differentiation, how best to mimic disease conditions, how to rein in stochasticity, and how to increase reproducibility and efficiency. Are micro or mesofluidic systems really the answer? Is there a minimal condition to produce these organoids? Is size limiting the complexity of these systems? Can time be sped up or slowed down in these systems? How and what do we measure to help addressing these questions?

"Engineering the Next Generation of Organoids" - Melissa Cadena
The ability to direct human somatic cells into induced pluripotent stem cells (iPSCs) has revolutionized the field of developmental neurobiology. Even more powerful is the development of protocols that promote self-organization of iPSCs into whole tissues or organs, often referred to as organoids. Using various protocols, we can now generate organoids that recapitulate various brain regions. These models can be used to study neurodevelopment, study developmental neurodegenerative, or neuropsychiatric disorders, and serve as a drug screening and discovery platform. Despite these advances, there remain several important limitations of brain organoids. Namely, the lack of cell type diversity seen in vivo, the absence of morphogen gradients, the lack of vasculature, and scalability.

This MCELS Seminar is a joint student lead seminar series by UIUC, GT, and MIT.


Additional Information

In Campus Calendar

Parker H. Petit Institute for Bioengineering and Bioscience (IBB), Wallace H. Coulter Dept. of Biomedical Engineering

Invited Audience
Faculty/Staff, Postdoc, Public, Graduate students, Undergraduate students
  • Created By: Colly Mitchell
  • Workflow Status: Published
  • Created On: Mar 15, 2021 - 4:26pm
  • Last Updated: Mar 17, 2021 - 9:06am