QBioS Student Seminar Series - Guanlin Li

Event Details
  • Date/Time:
    • Thursday February 11, 2021 - Friday February 12, 2021
      4:00 pm - 4:59 pm
  • Location: Event hosted virtually at https://bluejeans.com/558060212
  • Phone:
  • URL: Bluejeans
  • Email:
  • Fee(s):
    N/A
  • Extras:
Contact

Bluejeans link for the seminar is available here.

Contact Daniel Muratore (here) for questions. 

Summaries

Summary Sentence: QBioS Seminar Series - Guanlin Li

Full Summary: QBioS 4th year student Guanlin Li (homeschool of physics), advised by Joshua Weitz, will present "Optimizing use of multiphage ‘cocktails’ for treatment of immunodeficient hosts: a model-based control approach"

Media
  • qbios_seminar_02_11_2021_flyer qbios_seminar_02_11_2021_flyer
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Related Files

Optimizing use of multiphage ‘cocktails’ for treatment of immunodeficient hosts: a model-based control approach

The addition of therapeutic phage to treat Multi-Drug Resistant (MDR) pathogens imposes a strong selective pressure for the emergence of phage-resistant bacteria. Modeling and in vivo experiments have established that phage-resistant bacteria proliferate in Myd88-/- (immunodeficient) mice, corresponding to a failure of phage therapy. This work aims to develop evolutionarily robust phage therapy in immunodeficient hosts. First, we consider a model where bacteria evolve in an abstract discrete phenotypic space against different types of phages present in a therapeutic phage library. Second, we formulate a single-dose optimization problem subject to the proposed eco-evolutionary dynamics. The goal is to minimize the total bacterial population while penalizing the treatment costs by optimizing the phage therapy administrations. Finally, we extend single-dose treatment to multi-dose treatment and find the optimal policy via control theory. 

This seminar will be hosted at this bluejeans link.

Additional Information

In Campus Calendar
Yes
Groups

QBioS

Invited Audience
Faculty/Staff, Postdoc, Public, Graduate students, Undergraduate students
Categories
Seminar/Lecture/Colloquium
Keywords
go-qbios, go_qbios, QBioS, Qbios seminar
Status
  • Created By: dmuratore3
  • Workflow Status: Published
  • Created On: Feb 3, 2021 - 3:13pm
  • Last Updated: Feb 3, 2021 - 9:07pm