MS Defense by Yanina Kuzminich

Event Details
  • Date/Time:
    • Friday August 7, 2020 - Saturday August 8, 2020
      11:00 am - 12:59 pm
  • Location: REMOTE: BLUE JEANS
  • Phone:
  • URL: BlueJeans Link
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Summary Sentence: Non-Invasive Imaging of Lymphatic Remodeling In Response To Injury Through Photodynamic Therapy

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Yanina Kuzminich

BioE MS Defense


Date: Friday, August 7, 2020

Time: 11:00 AM

Location: BlueJeans (link below)



J. Brandon Dixon, PhD (Georgia Institute of Technology)



Erin Buckley, PhD (Emory University/Georgia Institute of Technology)

Rudolph Gleason, PhD (Georgia Institute of Technology)



Non-Invasive Imaging of Lymphatic Remodeling In Response To Injury Through Photodynamic Therapy


The lymphatic system is an essential but often understudied in comparison with its cardiovascular counterpart. Such disparity could often be explained by the lack or complexity of the existing imaging and analysis techniques available for the quantification of lymphatics compared to the ones available for the blood vasculature. An additional challenge is the absence of representative in vivo models that efficiently replicate the lymphatic dysfunction observed in humans. Those factors result in the continuous investigation of novel models for lymphatic diseases and ways to evaluate the overall function of the lymphatic system. Recently, it has been shown that verteporfin, a photosensitive drug widely used for photodynamic therapy (PDT) to ablate the blood vessels, provides a similar effect on lymphatic vessels. Here, we seek to administer verteporfin and perform PDT in the mouse tail, which is a commonly used location for the study of lymphatic disorders and examine lymphatic remodeling, contractility, and transport in response to the procedure. To quantify the induced changes, the lymphatic function has been evaluated using a near-infrared (NIR) imaging system. Additional image processing has been introduced to access the NIR tracer distribution following the lymphatic injury caused by the verteporfin administration. As a result, we are able to increase lymphatic permeability noninvasively at the targeted area. This technique has the potential to be a stand-alone procedure to investigate the lymphatic response to a localized leakage and ROS environment and serve as an improvement to existing in vivo models of lymphatic disorders.



Meeting URL

Meeting ID: 628745500

Additional Information

In Campus Calendar

Graduate Studies

Invited Audience
Faculty/Staff, Postdoc, Public, Graduate students
ms defense
  • Created By: Tatianna Richardson
  • Workflow Status: Published
  • Created On: Jul 27, 2020 - 6:25pm
  • Last Updated: Jul 27, 2020 - 6:25pm