PhD Proposal by Eashani Sathialingam

Event Details
  • Date/Time:
    • Thursday July 2, 2020 - Friday July 3, 2020
      2:00 pm - 3:59 pm
  • Location: REMOTE
  • Phone:
  • URL: BlueJeans Link
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Summary Sentence: The Theoretical and Translational Advancement of Diffuse Correlation Spectroscopy

Full Summary: No summary paragraph submitted.

Eashani Sathialingam

BME PhD Thesis Proposal Presentation


Date: 07/02/2020

Time: 2 pm



Committee Members:


Erin M. Buckley, PhD (Advisor)

Wilbur A. Lam, MD, PhD

Shella Keilholz, PhD

Brandon Dixon, PhD

Ofer Sadan, MD, PhD


Title: The Theoretical and Translational Advancement of Diffuse Correlation Spectroscopy


Cerebral blood flow is an important biomarker of brain health and function. Compromised blood flow may cause dangerous diseases in the brain such as stroke and subarachnoid hemorrhage. Diffuse correlation spectroscopy (DCS) is an emerging low-cost (<$50k), non-invasive, and portable optical modality that employs near-infrared light to measure an index of microvascular blood flow (BFI, cm2/s). While DCS BFI is proportional to blood flow, the dependence of BFI on red blood cell properties (i.e., flow velocity, vessel size, hematocrit, and morphology) is less understood. Therefore, the first aim of this proposal focuses on the theoretical advancement of DCS by using a microfluidic tissue-simulating phantom to explore the contribution of flow velocity, vessel size, and hematocrit on healthy and sickle cell blood. Understanding the DCS signal origins will improve the accuracy of DCS and increase the clinical applications of DCS. The second aim of this proposal demonstrates the clinical utility of DCS measurements of microvascular cerebral perfusion in patients with subarachnoid hemorrhage.

Additional Information

In Campus Calendar

Graduate Studies

Invited Audience
Faculty/Staff, Public, Graduate students, Undergraduate students
Phd proposal
  • Created By: Tatianna Richardson
  • Workflow Status: Published
  • Created On: Jun 18, 2020 - 4:51pm
  • Last Updated: Jun 18, 2020 - 4:51pm