Name: Dr. Spencer H. Bryngelson

Seminar Date: Tuesday, March 10, 2020

Seminar Time: 11:00 am

Seminar Location: CODA 230

Talk Title:  Computational and data-driven models in medicine: controlling cells and pulverizing stones

Talk Abstract: New biomedical devices and therapies are improving human health outcomes the world over. Still, they promise to do more if further developed and used effectively. The development of such devices can be accelerated by predictive simulation of the multi-physics biomechanics they entail. Even as exascale computing capabilities come online, fully detailed simulations remain out of reach.

Recent developments in machine learning and data assimilation are poised to change this paradigm through efficient use of available computational resources. New data-driven models for cell-scale cardiovascular flows and therapeutic bubble cavitation developed in this light are presented. High-fidelity spectral boundary integral and diffuse-interface solvers inform model design and lead to state-of-the-art predictions. MFC, our open-source software, showcases these capabilities. Analysis of the large-scale simulations guides biomicrofluidic device design and burst-wave lithotripsy administration. A holistic computational framework for the design of new therapies is proposed.

Bio:  Dr. Spencer Bryngelson is a Senior Postdoctoral Scholar at Caltech with Professor Tim Colonius. He also works with Professor Themis Sapsis at MIT on physics-informed machine-learned closures. Previously, he was a Postdoctoral Researcher at the Center for Exascale Simulation of Plasma-Coupled Combustion (XPACC), a PSAAP II center. He received his Ph.D. and M.S. in Theoretical and Applied Mechanics from the University of Illinois at Urbana–Champaign in 2017 and 2015, working with Professor Jonathan Freund. In 2013, he received B.S. degrees in both Mechanical Engineering and Engineering Mathematics from the University of Michigan–Dearborn.

Website: bryngelson-research.com