GT Neuro Seminar Series

Event Details
  • Date/Time:
    • Monday January 27, 2020
      11:15 am - 12:15 pm
  • Location: Krone Engineered Biosystems Building, Room 1005 - Atlanta, GA
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Garrett Stanley - faculty host


Summary Sentence: “A Functional Cortical Network for Sensorimotor Sequence Generation” - Daniel O’Connor, Ph.D. - Johns Hopkins University School of Medicine

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Daniel O’Connor, Ph.D.
Associate Professor 
Department of Neuroscience
Johns Hopkins University School of Medicine

“A Functional Cortical Network for Sensorimotor Sequence Generation”

I will discuss my laboratory’s recent work on the sensorimotor control of complex tongue movements. The brain generates complex sequences of movements that can be flexibly reconfigured in real-time based on sensory feedback, but how this occurs is not fully understood. We developed a novel ‘sequence licking’ task in which mice directed their tongue to a target that moved through a series of locations. Mice could rapidly reconfigure the sequence online based on tactile feedback. Closed-loop optogenetics and electrophysiology revealed that tongue/jaw regions of somatosensory (S1TJ) and motor (M1TJ) cortex encoded and controlled tongue kinematics at the level of individual licks. Tongue premotor (anterolateral motor, ALM) cortex encoded intended tongue angle in a smooth manner that spanned individual licks and even whole sequences, and progress toward the reward that marked successful sequence execution. ALM activity regulated sequence initiation, but multiple cortical areas collectively controlled termination of licking. Our results define a functional cortical network for hierarchical control of sensory- and reward-guided orofacial sequence generation.

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Additional Information

In Campus Calendar

Parker H. Petit Institute for Bioengineering and Bioscience (IBB)

Invited Audience
Faculty/Staff, Postdoc, Graduate students
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IBB, go-PetitInstitute, go-neuro
  • Created By: Floyd Wood
  • Workflow Status: Published
  • Created On: Jan 10, 2020 - 8:47am
  • Last Updated: Jan 10, 2020 - 8:47am