Utilizing Engineering Principles to Help Babies Born with "Half a Heart"

Event Details

Colly Mitchell (404) 894-5982


Summary Sentence: Ajit Yoganathan, PhD - Georgia Institute of Technology

Full Summary: IBB Breakfast Club SeminarAjit Yoganathan, PhD - The Wallace H. Coulter Distinguished Faculty Chair in Biomedical Engineering & Regents' Professor, Associate Chair for Research, Wallace H. Coulter School of Biomedical Engineering


Two in every one thousand births in the USA results in a baby born with a single ventricle (“half a heart”). The total cavopulmonary connection (TCPC) is the current procedure of choice for surgical palliation of single ventricle congenital heart disease. The hemodynamics/fluid dynamics in these patients is often very complex and subjected to instabilities. To better understand the fluid dynamics and predict patient outcomes, a synergistic multi-disciplinary approach, involving engineering, computing and medicine, has been utilized. Magnetic Resonance Imaging (MRI) has been used to obtain in vivo patient-specific anatomies and phase contrast MRI is used for flow boundary conditions. Computationally, a virtual surgery tool has been developed to simulate a series of surgical options, whose hemodynamic performances are evaluated using computational fluid dynamics (CFD).  Digital particle image velocimetry and energy loss measurements have also been employed to understand the fluid dynamics in vitro, in three dimensional geometric models of single ventricle patients. The experimental results provide validation to the CFD simulations. Using this multi-disciplinary approach, the performances of different patient geometries are evaluated based on their flow characteristics and hemodynamic efficiency. These findings are providing pediatric surgeons valuable surgical planning insights into improving patient outcomes.

Continental breakfast will be served.

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In Campus Calendar

Parker H. Petit Institute for Bioengineering and Bioscience (IBB)

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BK Club, IBB, Yoganathan
  • Created By: Colly Mitchell
  • Workflow Status: Published
  • Created On: Nov 1, 2010 - 8:00pm
  • Last Updated: Oct 7, 2016 - 9:53pm