GT Neuro Seminar Series

Event Details
  • Date/Time:
    • Monday February 5, 2018
      11:15 am - 12:15 pm
  • Location: Krone Engineered Biosystems Building, Room 1005 - Atlanta, GA
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Chris Rozell - faculty host


Summary Sentence: "A Systems Neuroscience Approach to Motor Recovery" - Karunesh Ganguly, M.D., Ph.D. - University of California, San Francisco

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“A Systems Neuroscience Approach to Motor Recovery”

Karunesh Ganguly, M.D., Ph.D. 
Associate Professor
Department of Neurology
University of California, San Francisco

It is commonly hypothesized that restoration of normal neural dynamics in the injured brain can improve function. However, we lack a precise neurophysiological framework for such an approach. Here we show that low-frequency oscillatory (LFO) dynamics play an important role in the execution of skilled behaviors in both the intact and injured brain. We chronically recorded local field potentials and spiking during motor training in both healthy and post-stroke rats. Interestingly, we found that task-related LFOs emerged with skilled performance under both conditions and were a robust predictor of recovery. We further hypothesized that boosting LFOs might improve function in animals with persistent deficits. Strikingly, we found that direct current stimulation could boost LFOs, and when applied in a novel, task-dependent manner, significantly improved function in those with chronic deficits. Together, our results demonstrate that LFOs are essential for skilled controlled and represent a novel target for modulation after injury.

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Additional Information

In Campus Calendar

Parker H. Petit Institute for Bioengineering and Bioscience (IBB)

Invited Audience
Faculty/Staff, Graduate students
go-PetitInstitute, go-neuro, gt neuro, gtneuro
  • Created By: Floyd Wood
  • Workflow Status: Published
  • Created On: Jan 29, 2018 - 9:46am
  • Last Updated: Jan 29, 2018 - 9:46am