BioE PhD Proposal Presentation- Aaron Enten

Event Details
  • Date/Time:
    • Wednesday January 31, 2018 - Thursday February 1, 2018
      1:00 pm - 2:59 pm
  • Location: CHOA EBB
  • Phone:
  • URL:
  • Email:
  • Fee(s):
    N/A
  • Extras:
Contact

Laura Paige

404-385-6655

Summaries

Summary Sentence: "Pulse Width Modulated Periodic Backflush to Improve Dead-End Filtration for Label-Free, Size-Based Sorting"

Full Summary: BioE PhD Proposal Presentation-  Pulse Width Modulated Periodic Backflush to Improve Dead-End Filtration for Label-Free, Size-Based Sorting -Aaron Enten

Thesis Advisor:

Todd Sulchek, PhD

Georgia Institute of Technology, Woodruff School of Mechanical Engineering

Thesis Committee:

Dr. Craig R. Forest, PhD
Georgia Institute of Technology, Woodruff School of Mechanical Engineering


Dr. Wilbur A. Lam, M.D. Ph.D
Georgia Institute of Technology and Emory University, Whitaker Biomedical Engineering

Dr. Manu Platt, Ph.D.

Georgia Institute of Technology and Emory University, Whitaker Biomedical Engineering

Dr. A. Fatih Sarioglu, Ph.D.

Georgia Institute of Technology, Electrical and Computer Engineering

 

Pulse Width Modulated Periodic Backflush to Improve Dead-End Filtration for Label-Free, Size-Based Sorting

Although label-free dead-end filtration cell sorting offers many advantages over other labelled and label-free approaches, it still falls short when comparing recovery percentage in most cases. Regardless, dead-end filters are used ubiquitously in clinical setting for diagnostic and therapeutic applications ranging from tissue engineering to infectious agent identification and stratification. Flow control has been shown to improve filter flux capacity over time, but no comprehensive breakdown of its waveform analysis has been performed and applied across the board. The central hypothesis of the proposed research is that pulse width modulation of fluid velocity can be used to periodically backflush dead-end membranes to interrupt cake formation, reintegrate fouling layers into the bulk of a sample, and improve permeate flux and recovery percentage. This will inform the design of fluid control dynamics for diagnostic as well as therapeutic application in Cystic Fibrosis, blood fractionation, and scaffold seeding. The effects of varying duty cycle to improve targeted permeate recovery percentage or retentate purity will be assessed through these applications.

Additional Information

In Campus Calendar
No
Groups

Bioengineering Graduate Program

Invited Audience
Faculty/Staff, Public, Undergraduate students
Categories
No categories were selected.
Keywords
No keywords were submitted.
Status
  • Created By: Laura Paige
  • Workflow Status: Published
  • Created On: Jan 19, 2018 - 8:21am
  • Last Updated: Jan 19, 2018 - 8:21am