BioE PhD Defense Presentation- Nathan Rohner

Event Details
  • Date/Time:
    • Friday May 5, 2017 - Saturday May 6, 2017
      12:00 pm - 1:59 pm
  • Location: 1128 IBB
  • Phone:
  • URL:
  • Email:
  • Fee(s):
    N/A
  • Extras:
Contact

Laura Paige

404-385-6655

Summaries

Summary Sentence: "ROLE OF VASCULAR REMODELING IN THE ACCUMULATION, CLEARANCE, AND BIODISTRIBUTION OF BIOMOLECULAR FACTORS IN MELANOMA"

Full Summary: BioE PhD Defense Presentation- "ROLE OF VASCULAR REMODELING IN THE ACCUMULATION, CLEARANCE, AND BIODISTRIBUTION OF BIOMOLECULAR FACTORS IN MELANOMA"- Nathan Rohner

Advisor: Susan N. Thomas, Ph.D. (Georgia Institute of Technology)

 

Committee:

Krishnendu Roy, Ph.D. (Georgia Institute of Technology)

Edward Botchwey, Ph.D. (Georgia Institute of Technology)

Fredrik Vannberg, Ph.D. (Georgia Institute of Technology)

Edmund Waller, M.D., Ph.D. (Emory University)

 

ROLE OF VASCULAR REMODELING IN THE ACCUMULATION, CLEARANCE, AND BIODISTRIBUTION OF BIOMOLECULAR FACTORS IN MELANOMA

 

Local inflammation within the tumor microenvironment is implicated in the systemic effects of disease progression, such as immune suppression and metastasis. Soluble factors (SF) produced within the tumor, including cytokines, exosomes, proteases, and microvesicles, mediate pathological signaling and have emerged as putative therapeutic targets. However, SF bioavailability in distributed tissues and the impact of disease progression on their dissemination profiles and exposure to various immune cell subsets is poorly defined. This stymies progress towards therapeutic amelioration of SF signaling activities to improve disease outcomes and is the critical knowledge gap this thesis seeks to fill. The central hypothesis is that tumor vascular remodeling redirects the organism-wide exposure of SF secreted locally within the tumor microenvironment, which may negatively contribute to disease burden by altering the bioavailability of molecules important to systemic disease progression. In this thesis, the effects of local tissue remodeling in melanoma leading to pathological SF accumulation profiles within distributed tissues are elucidated in order to provide insight into the potential for localized disease to exert systemic effects and inform opportunities to develop better preventive and curative treatment options for advanced melanomas.

Additional Information

In Campus Calendar
No
Groups

Bioengineering Graduate Program

Invited Audience
Faculty/Staff, Public, Undergraduate students
Categories
Conference/Symposium
Keywords
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Status
  • Created By: Laura Paige
  • Workflow Status: Published
  • Created On: Apr 20, 2017 - 8:55am
  • Last Updated: Apr 20, 2017 - 8:55am