GT Neuro Seminar Series

Event Details
  • Date/Time:
    • Monday March 27, 2017 - Tuesday March 28, 2017
      11:00 am - 11:59 am
  • Location: Engineered Biosystems Building (EBB), Room 1005 - Atlanta, GA
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Chris Rozell - faculty host


Summary Sentence: “How to Improve Detection and Treatment of Diabetic Retinopathy” - Machelle Pardue, Ph.D. - Georgia Tech

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“How to Improve Detection and Treatment of Diabetic Retinopathy”

Machelle Pardue, Ph.D.
Wallace H. Coulter Department of Biomedical Engineering
Georgia Tech/Emory University

Diabetic retinopathy (DR) is the leading cause of blindness in working age adults. DR is clinically diagnosed by late stage vascular changes in the retina. Detecting early stage retinopathy prior to the onset of these clinical findings would greatly impact the management and treatment of DR. We have identified several tests that show dysfunction in the retina prior to the onset of vascular lesions induced by diabetes. Using novel stimuli with the electroretinogram, we have determined that rod photoreceptor function is most vulnerable to diabetes. Our studies show similar delays in rodent models of diabetes and diabetic patients, prior to clinically diagnosed DR, suggesting a potential screening tool. In addition, we have shown that spatial frequency and contrast sensitivity thresholds decline prior to vascular changes when tested with moving gratings. Finally, we have demonstrated the application of reactive fluorescent tags to detect reactive oxygen species in the retina, providing another possible screening tool for DR. The detection of early stage DR opens a therapeutic window for neuroprotective agents that could slow or halt the progression of disease. We have demonstrated that L-DOPA or exercise treatments are promising interventions to slow the progression of DR and preserve visual function.

This presentation can be seen via videoconference on the Emory Campus HSRB E160

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Additional Information

In Campus Calendar

Parker H. Petit Institute for Bioengineering and Bioscience (IBB)

Invited Audience
Faculty/Staff, Undergraduate students, Graduate students
IBB, go-NeuralEngineering
  • Created By: Floyd Wood
  • Workflow Status: Published
  • Created On: Mar 9, 2017 - 12:29pm
  • Last Updated: Apr 13, 2017 - 5:12pm