GT Neuro Seminar Series

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All-Optical Electrophysiology, from Ion Channels to Brain

Adam Cohen, Ph.D.
Chemistry, Chemical Biology & Physics
Harvard University


To study a neural circuit, one would like to probe the activity of many neurons, with high resolution in space and time. A key challenge has been the difficulty of visualizing changes in transmembrane potential. We discovered that a protein derived from a Dead Sea microorganism could function as an exquisitely fast and sensitive fluorescent reporter of membrane voltage. We developed optical tools for simultaneous optical perturbation and optical readout of membrane voltage. Using these tools we have studied electrical activity in primary neurons /in vitro/, in acute brain slice, and in live mice. We have also studied human iPSC-based neuronal models of diseases such as pain, epilepsy, and ALS.Optical electrophysiology provides new insights into these complex bioelectric phenomena.

This presentation can be seen via videoconference on the Emory Campus HSRB E160


  • Workflow Status: Published
  • Created By: Floyd Wood
  • Created: 01/10/2017
  • Modified By: Fletcher Moore
  • Modified: 04/13/2017


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