2017 Suddath Award Presentation
The Parker H. Petit Institute for Bioengineering & Bioscience awards the Suddath Symposium graduate student awards to three students for their grand achievements in biological or biochemical research at the molecular or cellular level. The first place awardee presents their work to the Petit Institute community during the annual Suddath Symposium.
"Building a Model Prebiotic Nucleic Acid Replication Cycle in Viscous Environments"
2017 Suddath Award Winner
School of Chemical and Biomolecular Engineering
Martha Grover, Ph.D. - Advisor
Transfer of genetic information is a fundamental process in all living organisms. Many hypotheses concerning the nature of early life assume that genetic information was once transferred through the template-directed synthesis of RNA, prior to the evolution of genetically encoded protein synthesis. However, despite more than half a century of research into the chemical origins of nucleic acids, identifying a robust, prebiotically plausible route to template-directed nucleic acid synthesis remains an elusive goal.
In prebiotic conditions, copying of a nucleic acid duplex is limited by a biophysical problem know as strand inhibition: transferring information from a template strand in the presence of its complementary strand is inhibited by the stability of the template duplex. Here, I show that solvent viscosity can be utilized to overcome strand inhibition, enabling information transfer from a gene-length sequence (>300 nt) within a longer template duplex. These results suggest that viscous environments on the early Earth, generated by water evaporation, could have facilitated nucleic acid replication—particularly of long, structured sequences, such as ribozymes.
Lunch to be served immediately following presentation.
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