In my job talk a year ago I asked ‘can we make evolution-proof drugs?’, and offered theory and experimental evidence that this is possible. I showed that by targeting bacterial collective traits (eg. extracellular digestion) we can make drugs that select against resistance mutations. In this talk I will pick up on the problem I spelt out at the end of my job talk - our candidate ‘evolution proof’ treatments are sadly not the most effective drugs - and outline solutions that aim to restore and maintain the efficacy of our most potent drugs, our fading arsenal of old antibiotics. I will outline three overlapping strategies that we are currently developing - defusing resistance with adjuvants, killing resistant cells with phages and conditioning treatment choices on rapid and specific resistance diagnoses. In principle, these strategies offer a route to effective and evolutionarily robust treatments.