Petit Institute Seminar
"Interfacing Engineering, Biology and Medicine at the Micro and Nanoscale: From Lab-on-Chip to Building with Cells"
Rashid Bashir, Ph.D.
Abel Bliss Professor of Engineering
University of Illinois at Urbana-Champaign
Integration of biology, medicine, and fabrication methods at the micro and nano scale offers tremendous opportunities for solving important problems in biology and medicine and to enable a wide range of applications in diagnostics, therapeutics, and tissue engineering. Microfluidics and Lab-on-Chip can be very beneficial to realize practical applications in detection of disease markers, counting of specific cells from whole blood, and for identification of pathogens, at point-of-care. The use of small sample size and electrical methods for sensitive analysis of target entities can result in easy to use, one-time-use assays that can be used at point-of-care. In this talk, we will present our work on detection of T cells for diagnostics of HIV AIDs for global health, development of a CBC (Complete Blood Cell) analysis on a chip, electrical detection of multiplexed nucleic acid amplification reactions, and detection of epigenetic markers on DNA at the single molecule level. While the above mentioned devices are built with PDMS or silicon, bio-printing with stereolithography can be a very powerful technology to produce bio-hybrid devices made of polymers and cells such as biological machines and soft robotics. These devices could have potential applications in drug delivery, power generation, and other biomimetic systems.
Rashid Bashir is the Abel Bliss Professor of Engineering, and Professor of Bioengineering at the University of Illinois at Urbana-Champaign. He was the Director of the Micro and Nanotechnology Laboratory (mntl.illinois.edu), a campus-wide clean room facility from Oct 2007 to Aug 2013 and the Co-Director of the campus-wide Center for Nanoscale Science and Technology (www.cnst.illinois.edu), a “collaboratory” aimed at facilitating center grants and large initiatives around campus in the area of nanotechnology. Since Aug 2013, he is now the head of the Bioengineering department.
He has authored or co-authored over 200 journal papers, over 180 conference papers and conference abstracts, over 110 invited talks, and has been granted 37 patents. He is a fellow of IEEE, AIMBE, AAAS, APS, IAMBE, and BMES. His research interests include bionanotechnology, BioMEMS, lab on a chip, interfacing of biology and engineering from the molecular to the tissue scale, and applications of semiconductor fabrication to biomedical engineering, all applied to solving biomedical problems. He has been involved in 3 startups that have licensed his technologies (BioVitesse, Inc., Daktari Diagnostics, and most recently ElectroCyt).
In addition to leading his own research group, he is the PI on an NSF IGERT on Cellular and Molecular Mechanics and Bionanotechnology (2009-2016) and PI on an NIH Training Grant on Cancer Nanotechnology (2009 – 2016). He is also the campus lead and Co-PI on an NSF Science and Technology Center (STC) on Emergent Behavior of Integrated Cellular Systems (headquartered at MIT, with partners at Georgia Tech and UIUC) (2009 – 2015 and renewed for another 5 years 2015 – 2020).