Integrated Cancer Research Center Seminar

Event Details
  • Date/Time:
    • Tuesday March 15, 2016 - Wednesday March 16, 2016
      4:00 pm - 4:59 pm
  • Location: Parker H. Petit Institute for Bioengineering & Bioscience, Room 1128
  • Phone: (404) 894-6228
  • URL:
  • Email:
  • Fee(s):
  • Extras:

John McDonald, Ph.D. - faculty host


Summary Sentence: "Engineering Effector Proteins as Modulators of Cell Signaling Pathways for Breast Cancer Therapy" - Julie Champion, Ph.D. - Georgia Tech

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  • Integrated Cancer Research Center Integrated Cancer Research Center

"Engineering Effector Proteins as Modulators of Cell Signaling Pathways for Breast Cancer Therapy"

Julie A. Champion, Ph.D.
Assistant Professor
Tanner Junior Faculty Fellow
School of Chemical & Biomolecular Engineering
Georgia Tech

Bacterial pathogens trigger cell death by a variety of mechanisms, including injection of effector proteins. Effector proteins have great potential as anti-cancer agents because they efficiently subvert a variety of eukaryotic signaling pathways involved in cancer development, drug resistance, and metastasis. In this talk, I will discuss our use of YopJ, an effector from Yersinia pestis, as a potential breast cancer therapeutic. In breast cancer, MAPK and NFκB pathways are known to be dysregulated. YopJ down-regulates MAPK and NFκB pathways to induce cell death in specific cell types and we seek to exploit this infection-enabling protein for therapeutic use. We engineered YopJ to self-assemble into protein nanoparticles to efficiently deliver protein to cells, replacing the need for the pathogen secretion mechanism for effector delivery to host cells. YopJ nanoparticles induced dose and time-dependent death in multiple breast cancer cell lines. Treatment with sub-lethal doses of nanoparticles was still seen to be beneficial as well, decreasing metastasis-related behaviors and MAPK signaling. YopJ nanoparticles demonstrate the potential of engineered effector proteins as breast cancer therapeutics.

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Additional Information

In Campus Calendar

Parker H. Petit Institute for Bioengineering and Bioscience (IBB)

Invited Audience
Undergraduate students, Faculty/Staff, Graduate students
IBB, ICRC Seminar
  • Created By: Colly Mitchell
  • Workflow Status: Published
  • Created On: Mar 14, 2016 - 4:56am
  • Last Updated: Apr 13, 2017 - 5:16pm