Biofluids Seminar

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"A Novel Simulation Method for the Computation of Coronary Hemodynamics and its Clinical Validation"

Eun Bo Shim, Ph.D.
National Research Laboratory of Biosystems Engineering
Kangwon National University

In this seminar I introduce a vessel-length based simulation method to compute coronary fractional flow reserve. This method used the miscrovascular resistance values calculated from coronary vessel lengths. To validate the scheme for the computation of fractional flow reserve (FFR) based on coronary computed tomographic angiography (CCTA) data, we compared them with invasively measured FFR, and evaluated its diagnostic performance with that of CCTA. One hundred seventeen patients from 4 medical insti! tutions who had clinically indicated invasive coronary angiography for suspected coronary artery disease (CAD) were enrolled. Invasive FFR measurement was performed in 218 vessels (87 of which had an FFR ≤0.80); these measurements were regarded as the reference standard. The diagnostic characteristics of CCTA-derived computational FFR (CT-FFR) and CCTA were evaluated against those of invasively measured FFR. With a novel method of vessel-length based CFD scheme, CT-FFR can be easily performed at a personal computer enhancing its applicability in clinical situation. The diagnostic accuracy of CT-FFR for the detection of functionally significant CAD was good and was superior to that of CCTA within a population with a high prevalence of CAD. 



  • Workflow Status: Published
  • Created By: Colly Mitchell
  • Created: 02/24/2016
  • Modified By: Fletcher Moore
  • Modified: 04/13/2017