The 2016 George H. and Fay C. Sparks Forum on Ethics and Engineering

Event Details
  • Date/Time:
    • Thursday March 3, 2016 - Friday March 4, 2016
      10:00 am - 10:59 am
  • Location: Petit Institute, Room 1128
  • Phone:
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Karen Ethier


Summary Sentence: Somatic Cell Gene Therapy, Germline Gene Therapy and Gene Drives - Kenneth Oye, Ph.D. - MIT

Full Summary: No summary paragraph submitted.

Somatic Cell Gene Therapy, Germline Gene Therapy and Gene Drives

Efficient gene sequencing, enhanced analytic methods to identify targets, and accurate fast gene editing tools to make changes have contributed to a revolution in applied genomics. In the past year:

  • Over 300 somatic cell gene therapies to cure thalassemia, cystic fibrosis, hemophilia, and other illnesses are now under development.
  • The Zhang lab at Broad and the Joung lab at MGH developed what they have termed “high fidelity” CRISPR Cas9.
  • The Huang lab at Sun Yat-sen University Labs at Harvard, UCSD and UCSB demonstrated attempted human germline modification, editing the β-thalassaemia gene in 28 embryos.
  • Labs at Harvard, UCSD and UCSB demonstrated the ability to edit the genes of sexually reproducing plants and animals in the wild.

While all of these applications are enabled by CRISPR Cas9, the ethical, legal and economic challenges posed vary widely, with serious economic challenges for somatic gene therapy, with thorny ethical issues for developers and consumers of human germline modification, and with fundamental problems defining the appropriate scope and extent of consultation for first generation gene drives.

Keynote Speaker

Kenneth Oye is the Director of the MIT Program on Emerging Technologies, with a joint appointment in Political Science and Engineering Systems. Professor Oye serves as Director of Policy and Practices in NSF SynBERC, a faculty research lead at the MIT Center for Biomedical Innovation, a faculty affiliate of the MIT Synthetic Biology Center and a member of the Advisory Board of the International Risk Governance Council. His recent articles include pieces on gene drives in Science, on yeast based opiate production in Nature, on drug licensing in Clinical Pharmacology and Therapeutics, and on the environmental effects of synthetic biology in the Journal of Environmental Studies and Sciences. 

Additional Information

In Campus Calendar

Parker H. Petit Institute for Bioengineering and Bioscience (IBB)

Invited Audience
Undergraduate students, Faculty/Staff, Graduate students
  • Created By: Floyd Wood
  • Workflow Status: Published
  • Created On: Feb 9, 2016 - 8:19am
  • Last Updated: Apr 13, 2017 - 5:16pm