Petit Institute Seminar

Event Details
  • Date/Time:
    • Tuesday February 23, 2016 - Wednesday February 24, 2016
      10:00 am - 10:59 am
  • Location: Parker H.Petit Institute, Room 1128
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Nick Hud


Summary Sentence: "Fascinating NMR Structures of DNA Beyond Double Helix" - Janez Plavec, Ph.D. - University of Ljubljana, Slovenia

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"Fascinating NMR Structures of DNA Beyond Double Helix"

Janez Plavec, Ph.D.
Slovenian NMR Center
National Institute of Chemistry

University of Ljubljana, Slovenia

The distribution of G-rich sequences in the human genome is not random and their overrepresentation in the 5'-ends of human genes suggests that G-quadruplex formation may influence gene expression. G-quadruplexes are very structurally diverse. Numerous G-quadruplex structural characteristics indicate that even for relatively simple G-rich DNA or RNA sequences possible structural motifs are still not known entirely. It is impossible to unequivocally predict folding topology from oligonucleotide sequence and assess its thermodynamic stability at the current state of knowledge. Both are however crucial for understanding biological functions of G-quadruplexes as well as for the use of these noncanonical structures as targets in development of new anticancer and antiviral drugs and in nanotechnological applications. NMR studies have contributed important insight to the field over the years.

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In Campus Calendar

Parker H. Petit Institute for Bioengineering and Bioscience (IBB)

Invited Audience
Undergraduate students, Faculty/Staff, Graduate students
  • Created By: Floyd Wood
  • Workflow Status: Published
  • Created On: Jan 25, 2016 - 6:09am
  • Last Updated: Apr 13, 2017 - 5:16pm