Bioengineering Seminar Series

Event Details
  • Date/Time:
    • Thursday September 3, 2015 - Friday September 4, 2015
      11:00 am - 11:59 am
  • Location: Parker H. Petit Institute for Bioengineering & Bioscience, Room 1128
  • Phone: (404) 894-6228
  • URL:
  • Email:
  • Fee(s):
  • Extras:

Faculty host:  Hang Lu


Summary Sentence: "Multiscale Patient-specific Systems Biology" - Scott L. Diamond, Ph.D. - University of Pennsylvania

Full Summary: The Bioengineering Seminar Series is a joint seminar series between the Petit Institute and the Biomedical Engineering department. Seminars are held on Tuesdays or Thursdays between 11am-12pm in Petit Institute, Room 1128, unless otherwise indicated.

"Multiscale Patient-specific Systems Biology"

Scott L. Diamond, Ph.D.
Department of Chemical and Biomolecular Engineering
Institute for Medicine and Engineering
University of Pennsylvania

Predicting tissue function based upon an individual’s unique cells requires a multiscale Systems Biology approach to understand the coupling of intracellular signaling with spatiotemporal gradients of extracellular biochemicals.  Hundreds of spatiotemporal reactions proceed within activating platelets and the polymerizing plasma when blood clots under flow.  Clinically, excessive bleeding and clotting represent the two extremes of blood function that often concern patients and their doctors. Using high throughput experimentation, they obtained a large set of platelet responses to combinatorial activators in order to train a neural network (NN) model of platelet activation for several individuals. Each NN model was then embedded into a kinetic Monte Carlo/finite element/lattice Boltzmann simulation of stochastic platelet deposition under flow.  In silico representations of an individual’s platelet phenotype allowed prediction of blood function under flow (as measured using microfluidics), essential to prioritizing patient-specific cardiovascular risk and drug response or to identify unsuspected gene mutations.

Related Links

Additional Information

In Campus Calendar

Parker H. Petit Institute for Bioengineering and Bioscience (IBB)

Invited Audience
Undergraduate students, Faculty/Staff, Graduate students
BioE Seminar, go-immuno, graduate students, IBB
  • Created By: Karen Ethier
  • Workflow Status: Published
  • Created On: May 15, 2015 - 7:39am
  • Last Updated: Apr 13, 2017 - 5:19pm