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Timothy Formosa, University of Utah

The histone chaperone FACT and nucleosomes; some assembly required

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The histone chaperone FACT and nucleosomes; some assembly required

Histone chaperones bind to the abundant, basic, and hydrophobic histone proteins to prevent them from forming inappropriate interactions prior to their assembly into nucleosomes. However, chaperones also promote the assembly of nucleosomes. Structural, biochemical, and genetic results reveal how the essential histone chaperone FACT interacts with the four core histones, uncovering unexpected mechanisms for chaperone function, a previously unknown interaction motif for binding H2A-H2B dimers, and the surprisingly dynamic nature of the nucleosome itself.

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Thursday
Apr 30 2015
12:00pm - 12:00pm

Contact: If you have questions about logistics or would like to set up an appointment with the speaker, please contact the School of Biology's administrative office at bio-admin@biology.gatech.edu.

Phone: (404) 894-3700

In campus calendar: No

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  • Workflow Status:Published
  • Created By:Jasmine Martin
  • Created:01/21/2015
  • Modified By:Fletcher Moore
  • Modified:04/13/2017

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