Petit Institute Seminar

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"In vivo Knee Function in Response to Physiological Loading Conditions: Implications on Early Onset Osteoarthritis"

Louis E. DeFrate, PhD
Assistant Professor

Department of Orthopaedic Surgery
Duke University

Osteoarthritis is a degenerative joint disease that involves the degradation of articular cartilage. Osteoarthritis is one of the leading causes of disability in this country, affecting more than 27 million people in the U.S. Unfortunately, treatment for osteoarthritis is primarily limited to options such as physical therapy, pain management, and total joint replacement. In order to develop better treatment options to prevent the onset and progression of this disease, an improved understanding of the complex mechanisms leading to osteoarthritis is needed. This talk will focus on the relationship between altered loading of the knee and the development of early onset osteoarthritis. Specifically, innovative methodologies will be used to measure in vivo knee motion and cartilage deformation during activities of daily living in the presence of important risk factors for osteoarthritis such as obesity and joint injury.

The Petit Institute hosts special guests and visitors throughout the year. These seminars are open to all faculty and students.


  • Workflow Status: Published
  • Created By: Colly Mitchell
  • Created: 10/08/2014
  • Modified By: Fletcher Moore
  • Modified: 04/13/2017