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Martin Walsh, Icahn School of Medicine at Mount Sinai

Title: Regulating Energy and Lipid Metabolism through Pluripotent Transcriptional Networks

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Abstract:
Glycolysis and lipid biosynthesis are crucial to stem cell behavior, but we know little about the transcriptional regulation of factors driving metabolism in concert with stem cell fate. We demonstrate through use of selective BET-bromodomain inhibitors, and comprehensive RNA-seq and ChIP-seq analysis in mouse embryonic stem cells (ESCs), that Brd4, a master chromatin reader, governs transcription of the core pluripotency network and genes required for lipogenesis. Our studies now show that Brd4 governs glycolysis and lipogenesis at the core of the pluripotency framework of genes and that Brd4 regulates critical nodes of metabolism leading to the production of co-factors needed for modifying the epigenome.

Details

Tuesday
Mar 25 2014
09:00pm - 10:00pm

Contact: If you have questions about logistics or would like to set up an appointment with a speaker, please contact the School of Biology's Administrative office at bio-admin@biology.gatech.edu.

Phone: (404) 894-3700

In campus calendar: No

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  • Workflow Status:Published
  • Created By:Jasmine Martin
  • Created:03/20/2014
  • Modified By:Fletcher Moore
  • Modified:04/13/2017

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