Petit Institute Seminar

Event Details
  • Date/Time:
    • Thursday January 23, 2014 - Friday January 24, 2014
      11:00 am - 11:59 am
  • Location: Parker H. Petit Institute for Bioengineering & Bioscience, Room 1128
  • Phone: (404) 894-6228
  • URL:
  • Email:
  • Fee(s):
  • Extras:

Bob Guldberg, PhD


Summary Sentence: "Systems Tissue Engineering" - Lonnie D. Shea, MD - Northwestern University

Full Summary: The Petit Institute hosts special guests and visitors throughout the year.  These seminars are open to all faculty and students.

"Systems Tissue Engineering"

Lonnie D. Shea, PhD

Chemical & Biological Engineering
Northwestern University

Systems and strategies for promoting tissue growth provide enabling technologies for either enhancing regeneration for diseased or injured tissues, or to investigate abnormal tissue formation such as cancer. Given the complexity inherent in tissues, my laboratory is working towards the concept of "Systems Tissue Engineering", which indicates the dual need i) to develop systems capable of presenting combinations of factors that drive tissue growth, as well as ii) to incorporate systems biology approaches that can identify the appropriate combination of factors. Biomaterial scaffolds represent a central component of many approaches and provide the enabling tools for creating an environment and/or deliver factors that can direct cellular processes toward tissue formation. We have developed scaffolds with the objective of providing factors to stimulate growth and also blocking factors that inhibit regeneration, and will illustrate this approach through our work with islet transplantation in Type 1 Diabetes therapy and scaffolds for the early detection of cancer. The immune response has become a central focus, and will present results for local immunomodulation around the scaffold, as well as the development of nanoparticles for modulating the immune response, in order to induce tolerance in autoimmune disease and allogeneic cell transplantation.  The ability to present multiple factors raises the challenge of identifying the combination that will maximally promote tissue formation. Toward this goal, we have developed a cellular array for the large scale profiling of transcription factor activity throughout tissue formation, which we propose can identify the factors necessary to drive cells towards the desired phenotype. This array represents a novel systems biology tool for molecularly dissecting tissue formation. This approach of relating tissue development to molecular design of the scaffold may ultimately lead to the formation of engineered tissues that could provide alternatives to whole organ or tissue transplantation.

Bob Guldberg, PhD - faculty host


Related Links

Additional Information

In Campus Calendar

Parker H. Petit Institute for Bioengineering and Bioscience (IBB), Bioengineering Graduate Program

Invited Audience
Undergraduate students, Faculty/Staff, Graduate students
IBB, IBB Seminar
  • Created By: Colly Mitchell
  • Workflow Status: Published
  • Created On: Jan 10, 2014 - 6:15am
  • Last Updated: Apr 13, 2017 - 5:23pm