Integrated Cancer Research Seminar Series

Event Details

John McDonald, PhD


Summary Sentence: "Glycoproteomic Discovery of Cancer Biomarkers" - Karen L. Abbott, PhD - University of Georgia

Full Summary: Georgia Tech has been a leader in the development of collaborative approaches to both cancer diagnostics and therapeutics. The mission of the Integrated Cancer Research Center (ICRC) is to facilitate integration of the diversity of technological, computational, scientific and medical expertise at Georgia Tech and partner institutions in a coordinated effort to develop improved cancer diagnostics and therapeutics.

  • Karen L. Abbott, PhD - University of Georgia Karen L. Abbott, PhD - University of Georgia

"Glycoproteomic Discovery of Cancer Biomarkers"

Karen L. Abbott, PhD
Assistant Research Professor
Complex Carbohydrate Research Center
University of Georgia

Glycosylation is a posttranslational modification that changes early in cancer cells favoring the growth and progression of the tumor.  We have developed glycoproteomic techniques that enable the identification of glycoproteins that carry tumor-specific glycans using lectin capture followed by nano-ESI-RPLC-MS/MS analysis.  The application of these methods for breast and ovarian cancer has led to the identification of new biomarkers that are common to diverse molecular and histological subtypes of breast and ovarian cancer.  These results indicate that the detection of tumor-specfic glycan changes on specific glycoproteins may be useful for the development of population wide screening for breast and ovarian cancers.  Furthermore, these studies offer new insights into functional roles of tumor-specific glycan modifications that may be exploited for the development of future therapeutics.      

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In Campus Calendar

Parker H. Petit Institute for Bioengineering and Bioscience (IBB)

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IBB, ICRC Seminar
  • Created By: Colly Mitchell
  • Workflow Status: Published
  • Created On: Dec 13, 2012 - 10:29am
  • Last Updated: Oct 7, 2016 - 10:01pm