Laser Microbeams in the Study of Mechanobiology

Event Details
  • Date/Time:
    • Tuesday October 23, 2012 - Wednesday October 24, 2012
      11:00 am - 11:59 am
  • Location: Parker H. Petit Institute for Bioengineering & Bioscience, Rm. 1128
  • Phone: (404) 894-6228
  • URL:
  • Email:
  • Fee(s):
  • Extras:

Tom Barker or Andres Garcia


Summary Sentence: Petit Institute Seminar - Elliot Botvinick, PhD - Columbia University

Full Summary: Elliot Botvinick, PhD, assistant professor at University of California - Irvine, will give a seminar at the Petit Institute.

Elliot Botvinick, PhD
Assistant Professor
University of California - Irvine

The Botvinick lab implements laser microbeams to study mechanics in cell signaling and function. During his seminar, he will present three projects.

(1) A biophysical study of Notch signaling. The Notch signaling mechanism is peculiar in that it requires competent endocytosis in the ligand cell. The Botvinick lab uses optical tweezers to argue Notch signaling is dependent on specific endocytic components and the generation of ‘strong’ endocytic forces. Additionally, they have strong evidence that receptor-ligand bond strength is independent of ligand endocytosis and recycling.

(2) Optical Microrheology. The Botvinick lab uses optical microrheology to map ECM mechanical properties surrounding cells cultured in 3-D. They combine this with a shear gradient device to test the role of local stiffness in cell differentiation and function.

(3) Micro-tsunamis. This is a new all-optical tool for the study of mechano transduction. The Botvinick lab uses a single focused laser pulse to excite mechano-signaling in hundreds of cells. Botvinick will demonstrate the utility of micro-tsunamis for the detection of drug-induced changes in cellular mechanotransduction.

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In Campus Calendar

Parker H. Petit Institute for Bioengineering and Bioscience (IBB)

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elliot botvinick, IBB, IBB Events, IBB Seminar
  • Created By: Megan McDevitt
  • Workflow Status: Published
  • Created On: Oct 16, 2012 - 11:44am
  • Last Updated: Oct 7, 2016 - 10:00pm